{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:21:14Z","timestamp":1775640074739,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Platelet microRNAs (miRs) have been indicated as a diagnostic biomarker in various diseases, including acute coronary syndrome (ACS). This study aimed to investigate the expression of miR-223-5p, miR-126-5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty subjects with CAD and 13 healthy individuals were under study. The expression of miR-223-5p, miR-126-5p, miR-484, and miR-130a-3p was measured in platelets by quantitative reverse transcription\u2013polymerase chain reaction. The relationship between miRNA expression and various parameters of the subjects was analyzed using analysis of variance and Spearman and t-tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The miR-484 expression was significantly upregulated in the ACS subjects (P\u2005=\u2005.0097). Moreover, miR-484 had diagnostic value for screening subjects with unstable angina vs controls (area under the curve [AUC]\u2005=\u20050.978, 95% confidence interval [CI] 0.92\u20131, P\u2005=\u2005.0006) and NSTEMI patients versus controls (AUC\u2005=\u20050.910, 95% CI 0.74\u20131, P\u2005=\u2005.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results of this study indicate that the upregulated expression of miR-484 in ACS patients might be used as a diagnostic biomarker in ACS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmac102","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T20:09:30Z","timestamp":1665432570000},"page":"256-261","source":"Crossref","is-referenced-by-count":12,"title":["Platelet MicroRNA-484 as a Novel Diagnostic Biomarker for Acute Coronary Syndrome"],"prefix":"10.1093","volume":"54","author":[{"given":"Parisa","family":"Masoodi Khabar","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Esmail","family":"Ghydari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Taleghani General Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Vazifeh Shiran","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Shirazy","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Hamidpour","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Research Centre \u2013 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"issue":"3","key":"2023050216514944300_CIT0001","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/ATVBAHA.114.303401","article-title":"Role of oral anticoagulants in patients after an acute coronary 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