{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:29:02Z","timestamp":1762064942645,"version":"build-2065373602"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was to study the use of prostatic exosomal protein (PSEP) and prostate-specific antigen (PSA) in diagnosis of prostate-related diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 54 cases of acute prostatitis (AP), 72 cases of chronic prostatitis (CP), and 36 cases of prostate cancer (PCa) were enrolled. Levels of PSEP and PSA were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The positive rate and level of PSEP in CP was highest (both P\u2005&amp;lt;\u2005.05). The total PSA (tPSA) level in PCa was the highest (P\u2005&amp;lt;\u2005.05), followed by AP and CP. The free PSA (fPSA) level was lowest in CP (P\u2005&amp;lt;\u2005.05); fPSA\/tPSA in AP was the highest (P\u2005&amp;lt;\u2005.05). The PSEP level in type II CP was higher than in type IIIa and type IIIb (both P\u2005&amp;lt;\u2005.05), and it was higher in type IIIa than in type IIIb (P\u2005&amp;lt;\u2005.05). The tPSA level in type IIIb was the lowest in the 3 types (both P\u2005&amp;lt;\u2005.05). The fPSA\/tPSA in type IIIb was the highest in the 3 types (P\u2005&amp;lt;\u2005.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PSEP combined with PSA better distinguishes prostate-related diseases.<\/jats:p><\/jats:sec>","DOI":"10.1093\/labmed\/lmac103","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T20:09:29Z","timestamp":1665432569000},"page":"212-214","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Application of Prostatic Exosomal Protein and Prostate-Specific Antigen Levels in the Detection of Prostate-Related Diseases"],"prefix":"10.1093","volume":"54","author":[{"given":"Qiuxia","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital of Nanjing Medical University , Nanjing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfang","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital of Nanjing Medical University , Nanjing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"issue":"6","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00120-020-01226-5","article-title":"Chronic prostatitis\/chronic pelvic pain syndrome","volume":"59","author":"Magistro","year":"2020","journal-title":"Der Urologe Ausg A."},{"issue":"5","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"e0154507","DOI":"10.1371\/journal.pone.0154507","article-title":"Urine exosomes for non-invasive assessment of gene expression and mutations of prostate cancer","volume":"11","author":"Motamedinia","year":"2016","journal-title":"PLoS One."},{"issue":"1","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000479188","article-title":"Clinical evaluation of urine prostatic exosomal protein in the diagnosis of chronic prostatitis","volume":"100","author":"Li","year":"2018","journal-title":"Urol Int."},{"issue":"5","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.21037\/tau-20-1268","article-title":"A urine-based biomarker for chronic prostatitis\/chronic pelvic pain syndrome: a retrospective multi-center study","volume":"9","author":"Liang","year":"2020","journal-title":"Transl Androl Urol."},{"issue":"33","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"e16848e16848","DOI":"10.1097\/MD.0000000000016848","article-title":"The application of IL-10 and TNF-\u03b1 in expressed prostatic secretions and prostatic exosomal protein in urine in the diagnosis of patients with chronic prostatitis","volume":"98","author":"Yin","year":"2019","journal-title":"Medicine."},{"issue":"6","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"e23778","DOI":"10.1002\/jcla.23778","article-title":"The diagnostic value of urine heat shock protein 70 and prostatic exosomal protein in chronic prostatitis","volume":"35","author":"Tang","year":"2021","journal-title":"J Clin Lab Anal."},{"issue":"1","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4111\/icu.20200395","article-title":"Clinical utility of current biomarkers for prostate cancer detection","volume":"62","author":"Kim","year":"2021","journal-title":"Investig Clin Urol."},{"issue":"5","key":"2023030723490788700_","first-page":"1074","article-title":"Clinical significance of urine prostatic exosomal protein in the diagnosis of prostate cancer","volume":"9","author":"Gu","year":"2019","journal-title":"Am J Cancer Res."},{"issue":"4","key":"2023030723490788700_","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.21037\/tau-20-1210","article-title":"Extracellular vesicles in prostate cancer: a narrative review","volume":"10","author":"Hatano","year":"2021","journal-title":"Transl Androl Urol."}],"container-title":["Laboratory 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