{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:46:52Z","timestamp":1780386412975,"version":"3.54.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Chengdu Municipal Health Commission","award":["2021178"],"award-info":[{"award-number":["2021178"]}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["YYZX2021142"],"award-info":[{"award-number":["YYZX2021142"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We evaluated the intraday changes of thyroid function biomarkers in healthy subjects to help clinicians diagnose thyroid diseases in appropriate timing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Blood samples were collected from 31 subjects at 0:00, 4:00, 8:00, 12:00, 16:00 and 20:00 on the sampling day and analyzed for thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), and free T4 (FT4). The intraday concentration changes were analyzed using Friedman\u2019s 2-way analysis of variance by ranks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The concentrations of TSH, T3, T4, FT3, and FT4 in males were significantly higher than those in females (P\u2005&amp;lt;\u2005.01). The obvious peak circadian rhythm of TSH was observed at 0:00 AM with gradual decline thereafter, whereas other biomarkers showed no rhythmic changes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Sex differences should be considered in interpreting thyroid function tests. It is important to select the sampling time according to the clinician\u2019s diagnostic needs, especially at night when TSH secretion peaks.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmac105","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T07:17:43Z","timestamp":1665559063000},"page":"282-286","source":"Crossref","is-referenced-by-count":4,"title":["Intraday Changes and Clinical Applications of Thyroid Function Biomarkers in Healthy Subjects"],"prefix":"10.1093","volume":"54","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Qiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Hai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Chuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Rong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Rui","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of the Pidu District, Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"issue":"2","key":"2023050216515500200_CIT0001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol Rev."},{"key":"2023050216515500200_CIT0002","article-title":"Physiology, thyroid hormone.","volume-title":"StatPearls","author":"Shahid"},{"key":"2023050216515500200_CIT0003","doi-asserted-by":"crossref","first-page":"106389","DOI":"10.1016\/j.domaniend.2019.106389","article-title":"Short-term biological variation of serum thyroid hormones concentrations in clinically healthy cats","volume":"71","author":"Prieto","year":"2020","journal-title":"Domest Anim Endocrinol."},{"issue":"1","key":"2023050216515500200_CIT0004","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3109\/07435800.2012.710696","article-title":"Clinical significance of TSH circadian variability in patients with hypothyroidism","volume":"38","author":"Sviridonova","year":"2013","journal-title":"Endocr Res."},{"key":"2023050216515500200_CIT0005","author":"Aarsand"},{"issue":"5","key":"2023050216515500200_CIT0006","first-page":"135","article-title":"Value of using reference change factor to evaluate the results of continuous monitoring of thyroid function indicators in thyroid diseases","volume":"34","author":"Zhang","year":"2019","journal-title":"J. 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Commemoration of the 5th Anniversary of the Chinese Society for the Microbiology Clinical Microbiology Specialized Committee. Compilation of the 5th Chinese Congress of Clinical Microbiology & Microbiology and Immunology Forum across the Taiwan Strait","author":"Zhang","year":"2014"},{"key":"2023050216515500200_CIT0012","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/jcem-70-2-403","article-title":"Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman","volume":"70","author":"Brabant","year":"1990","journal-title":"J Clin Endocrinol Metab."},{"issue":"019","key":"2023050216515500200_CIT0013","first-page":"2646","article-title":"Study on the reference ranges of serum thyroid hormones in healthy population aged from 18 to 60 years in Haikou","volume":"000","author":"Pan","year":"2014","journal-title":"Int J Lab Med."}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/54\/3\/282\/50171275\/lmac105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/54\/3\/282\/50171275\/lmac105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T17:18:24Z","timestamp":1683047904000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/54\/3\/282\/6759112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,10,12]]},"published-print":{"date-parts":[[2023,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmac105","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2022,10,12]]}}}