{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:35:14Z","timestamp":1751376914448},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The Choosing Wisely initiative recommended cessation of folate measurement, suggesting folate supplementation in macrocytic anemia. This study reviewed the need for continued blood folate testing at a large SafetyNet county teaching hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Red blood cell (RBC) folate, vitamin B12, iron, ferritin, and hemoglobin results were obtained for utilization review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 593 RBC folate results, 69 (11.7%) were deficient and 30 (5%) had high values. Collectively, 369 (73.9%) had normal vitamin B12 levels, 342 (70%) had low hemoglobin, 184 (62.5) had normal and 57 (19.4%) had low ferritin, 122 (38.2%) had normal and 188 (59%) had low iron levels. A\u00a0total of 41 (12%) had normal folate, low ferritin, low hemoglobin, and low iron, suggestive of iron deficiency anemia. There were 11 patients who exhibited low folate, low or normal ferritin, low hemoglobin, and low iron levels, suggesting combined folate and iron deficiency anemias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study highlights the need for institutions to assess the applicability of national recommendations to their local population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmac148","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T01:27:04Z","timestamp":1673659624000},"page":"424-428","source":"Crossref","is-referenced-by-count":2,"title":["The Continued Need for the Routine Assessment of Folate Status"],"prefix":"10.1093","volume":"54","author":[{"given":"Bremansu","family":"Osa-Andrews","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center , Dallas, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Parkland Hospital System , Dallas, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim\u00a0A","family":"Hashim","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center , Dallas, TX , USA"},{"name":"Department of Pathology, Parkland Hospital System , Dallas, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"issue":"3","key":"2023070507325870200_CIT0001","doi-asserted-by":"crossref","first-page":"477","DOI":"10.5858\/2007-131-477-DNFFMA","article-title":"Diminished need for folate measurements among indigent populations in the post folic acid supplementation era","volume":"131","author":"Joelson","year":"2007","journal-title":"Arch Pathol Lab Med."},{"issue":"2","key":"2023070507325870200_CIT0002","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcn\/82.2.442","article-title":"Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000","volume":"82","author":"Pfeiffer","year":"2005","journal-title":"Am J Clin Nutr."},{"key":"2023070507325870200_CIT0003","volume-title":"ABC\u2019s of Interpretative Laboratory Data","author":"Bakerman","year":"2014","edition":"5"},{"issue":"5","key":"2023070507325870200_CIT0004","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/jgf2.31","article-title":"Diagnosis and treatment of macrocytic anemias\u00a0in adults","volume":"18","author":"Nagao","year":"2017","journal-title":"J Gen Fam Med."},{"key":"2023070507325870200_CIT0005","author":"Wallace"},{"issue":"6","key":"2023070507325870200_CIT0006","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/jnci\/djp019","article-title":"Folic acid and risk of prostate cancer: results from a randomized clinical trial","volume":"101","author":"Figueiredo","year":"2009","journal-title":"J Natl Cancer Inst."},{"issue":"19","key":"2023070507325870200_CIT0007","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1001\/jama.2009.1622","article-title":"Cancer incidence and mortality after treatment with folic acid and vitamin B12","volume":"302","author":"Ebbing","year":"2009","journal-title":"JAMA."},{"issue":"2","key":"2023070507325870200_CIT0008","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ejcn.2016.194","article-title":"The adverse effects of an excessive folic acid intake","volume":"71","author":"Patel","year":"2017","journal-title":"Eur J Clin Nutr."},{"key":"2023070507325870200_CIT0009","article-title":"Vitamin B12 deficiency.","volume-title":"StatPearls","author":"Ankar","year":"2021"},{"key":"2023070507325870200_CIT0010","article-title":"Megaloblastic anemia.","volume-title":"StatPearls","author":"Hariz","year":"2021"},{"key":"2023070507325870200_CIT0011","author":"Pirkle"},{"key":"2023070507325870200_CIT0012","author":"Rosenthal"},{"key":"2023070507325870200_CIT0013","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1756-0500-3-22","article-title":"Ordering folate assays is no longer justified for investigation of anemias, in folic acid fortified countries","volume":"3","author":"Shojania","year":"2010","journal-title":"BMC Res Notes."},{"key":"2023070507325870200_CIT0014","doi-asserted-by":"crossref","first-page":"k724","DOI":"10.1136\/bmj.k724","article-title":"Do the benefits of folic acid fortification outweigh the risk of masking vitamin B12 deficiency?","volume":"360","author":"Mills","year":"2018","journal-title":"BMJ."},{"issue":"8 pt 2","key":"2023070507325870200_CIT0015","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/clinchem\/46.8.1277","article-title":"Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate","volume":"46","author":"Klee","year":"2000","journal-title":"Clin Chem."},{"key":"2023070507325870200_CIT0016"}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/54\/4\/424\/50781362\/lmac148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/54\/4\/424\/50781362\/lmac148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T16:46:54Z","timestamp":1688575614000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/54\/4\/424\/6986983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,1,13]]},"published-print":{"date-parts":[[2023,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmac148","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7,1]]},"published":{"date-parts":[[2023,1,13]]}}}