{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:26Z","timestamp":1753877246499,"version":"3.41.2"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LBY23H200009"],"award-info":[{"award-number":["LBY23H200009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this work was to compare different local cutoff values (LCV) and inline cutoff values (ICV) in pregnant women in the second\u00a0trimester at high risk for carrying fetuses with trisomy\u00a021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study analyzed prenatal screening outcomes in pregnant women (n\u00a0=\u00a0311,561). The receiver operating characteristic curve was used to evaluate the diagnostic significance of the trisomy 21 risk value, alpha-fetoprotein, and free beta human chorionic gonadotropin multiple of the median for predicting trisomy 21 risk. The cutoff value corresponding to the maximal Youden index was taken as the LCV. The screening efficiency of both cutoff values was compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The LCV cutoff value was lower than the ICV cutoff value (1\/643 vs 1\/270). The sensitivity increased by 19.80%, the positive predictive value decreased by 0.20%, and the false-positive rate increased by 6.50%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The LCV should be used to determine trisomy 21 risk, which can increase the detection rate of trisomy 21 in the second trimester.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmad015","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T17:31:16Z","timestamp":1681407076000},"page":"603-607","source":"Crossref","is-referenced-by-count":0,"title":["The importance of the trisomy 21 local cutoff value evaluation for prenatal screening in the second trimester of pregnancy"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1532-6049","authenticated-orcid":false,"given":"Chen","family":"Yiming","sequence":"first","affiliation":[{"name":"Departments of Prenatal Diagnosis and Screening Center, Zhejiang Chinese Medical University , Hangzhou , China"},{"name":"Department of the Fourth School of Clinical Medical, Zhejiang Chinese Medical University , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of the Fourth School of Clinical Medical, Zhejiang Chinese Medical University , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical &#x2028;Laboratory, Hangzhou Women\u2019s Hospital (Hangzhou Maternity and Child Health Care Hospital) , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyao","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Prenatal Diagnosis and Screening Center, Zhejiang Chinese Medical University , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of the Fourth School of Clinical Medical, Zhejiang Chinese Medical University , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"issue":"9","key":"2023110721225318700_CIT0001","doi-asserted-by":"crossref","first-page":"e380","DOI":"10.1016\/j.jogc.2017.06.013","article-title":"No. 261-Prenatal screening for fetal aneuploidy in singleton pregnancies","volume":"39","author":"Chitayat","year":"2017","journal-title":"J Obstet Gynaecol 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