{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:38:17Z","timestamp":1765233497590,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Guangzhou Basic and Applied Basic Research project","award":["202102021139"],"award-info":[{"award-number":["202102021139"]}]},{"name":"Science and technology research project of traditional Chinese Medicine of Guangdong Provincial Hospital of Chinese Medicine","award":["YN2019QL06"],"award-info":[{"award-number":["YN2019QL06"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2020A1515110329"],"award-info":[{"award-number":["2020A1515110329"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dampness Syndrome of Chinese Medicine","award":["SZ2021ZZ24"],"award-info":[{"award-number":["SZ2021ZZ24"]}]},{"name":"Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases","award":["2018B030322012"],"award-info":[{"award-number":["2018B030322012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aims to estimate the prevalence of anti-mitochondrial antibody subtype M2 (AMA-M2) and assess its consistency with AMA in a general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 8954 volunteers were included to screen AMA-M2 using enzyme-linked immunosorbent assay. Sera with AMA-M2\u00a0&amp;gt;50 RU\/mL were further tested for AMA using an indirect immunofluorescence assay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The population frequency of AMA-M2 positivity was 9.67%, of which 48.04% were males and 51.96% were females. The AMA-M2 positivity in males had a peak and valley value of 7.81% and 16.88% in those aged 40 to 49 and \u226570\u00a0years, respectively, whereas it showed a balanced age distribution in females. Transferrin and immunoglobulin M were the risk factors for AMA-M2 positivity and exercise was the only protective factor. Of 155 cases with AMA-M2\u00a0&amp;gt;50 RU\/mL, 25 cases were AMA-positive, with a female-to-male ratio of 5.25:1. Only 2 people, with very high AMA-M2 of 760 and &amp;gt;800 RU\/mL, met the diagnostic criteria of primary biliary cholangitis (PBC), making the prevalence of PBC 223.36 per million in southern China.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We found that AMA-M2 has a low coincidence rate with AMA in the general population. A\u00a0new decision-making point for AMA-M2 is needed to improve consistency with AMA and diagnostic accuracy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmad018","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T20:58:36Z","timestamp":1681246716000},"page":"618-625","source":"Crossref","is-referenced-by-count":2,"title":["A population-based characterization study of &amp;#x2028;anti-mitochondrial M2 antibodies and its consistency with anti-mitochondrial antibodies"],"prefix":"10.1093","volume":"54","author":[{"given":"En-yu","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou , China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou , 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