{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T17:09:06Z","timestamp":1763831346262,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Double trisomies are rare findings among products of conception and are often lethal to the developing embryo or fetus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Here we describe a double trisomy case with symptoms of threatened miscarriage at 9 weeks gestation. Ultrasound revealed an anembryonic pregnancy. Pregnancy was terminated by dilation and curettage at gestational age 11 weeks and 6 days. Histologic examination and chromosome microarray were performed on a formalin-fixed product of conception (POC) sample to identify the cause of the anembryonic pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Chromosome microarray analysis revealed a female chromosome complement with double trisomies 10 and 20, arr(10,20)x3, consistent with a karyotype of 48,XX,+10,+20.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>To the best of our knowledge, this is the first reported case of double trisomy 10 and 20 in a POC. Due to nonspecific histopathological findings, chromosomal microarray is a powerful tool in identifying and differentiating chromosomal aneuploidies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmad052","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T20:18:44Z","timestamp":1686341924000},"page":"245-248","source":"Crossref","is-referenced-by-count":1,"title":["The first reported case of double trisomy 10 and 20 in a product of conception"],"prefix":"10.1093","volume":"55","author":[{"given":"Joshua","family":"Fernandez De La Vega","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arian Pourmehdi","family":"Lahiji","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-1996","authenticated-orcid":false,"given":"Caitlin","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshwardhan","family":"Thaker","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-6132","authenticated-orcid":false,"given":"Jianli","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX , US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2024030806191468400_CIT0001","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/gim.2016.69","article-title":"Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges","volume":"19","author":"Sahoo","year":"2017","journal-title":"Genet Med."},{"key":"2024030806191468400_CIT0002","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.GIM.0000160075.96707.04","article-title":"Incidence and spectrum of chromosome abnormalities in spontaneous abortions: new insights from a 12-year study","volume":"7","author":"Menasha","year":"2005","journal-title":"Genet Med."},{"key":"2024030806191468400_CIT0003","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s004390050638","article-title":"Double trisomy in spontaneous abortions","volume":"101","author":"Reddy","year":"1997","journal-title":"Hum Genet."},{"key":"2024030806191468400_CIT0004","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1093\/humrep\/dei406","article-title":"Double trisomy in spontaneous miscarriages: cytogenetic and molecular approach","volume":"21","author":"Diego-Alvarez","year":"2006","journal-title":"Hum Reprod."},{"author":"Scherer","key":"2024030806191468400_CIT0005"},{"key":"2024030806191468400_CIT0006","doi-asserted-by":"crossref","first-page":"e262","DOI":"10.1097\/AOG.0000000000001817","article-title":"Committee opinion No.682: microarrays and next-generation sequencing technology: the use of advanced genetic diagnostic tools in obstetrics and gynecology","volume":"128","author":"Vora","year":"2016","journal-title":"Obstet Gynecol"},{"key":"2024030806191468400_CIT0007","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/gim.2013.129","article-title":"ACMG standards and guidelines for constitutional cytogenomic microarray analysis, including postnatal and prenatal applications: revision 2013","volume":"15","author":"South","year":"2013","journal-title":"Genet Med."},{"key":"2024030806191468400_CIT0008","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genom-092010-110715","article-title":"Copy number and SNP arrays in clinical diagnostics","volume":"12","author":"Schaaf","year":"2011","journal-title":"Annu Rev Genomics Hum Genet."},{"key":"2024030806191468400_CIT0009","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/pd.5422","article-title":"Are all chromosome microarrays the same? 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