{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:19:05Z","timestamp":1740136745044,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province","award":["2022E10022"],"award-info":[{"award-number":["2022E10022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to investigate the diagnostic potential of Krebs von den Lungen-6 (KL-6) in differentiating between malignant pleural effusion (MPE) induced by non\u2013small cell lung cancer (NSCLC) and benign pleural effusion (BPE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected 143 pleural effusion samples from August 2018 to March 2021. The samples included 91 cases of MPE and 52 cases of BPE. The KL-6 and other indicators in pleural effusion were detected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The level of pleural effusion KL-6 (pKL-6) in the MPE group was significantly higher than in the BPE group (Mann-Whitney U = 442.500, P = .000). The area under the curve (AUC) of pKL-6\/pleural effusion adenosine deaminase (pADA) + pleural effusion carcinoembryonic antigen (pCEA)\/pADA (AUC = 0.992) in diagnosing MPE was higher than that of pKL-6 alone (AUC = 0.903), with a sensitivity of 93.26% and specificity of 100%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The measurement of pKL-6 can differentiate NSCLC-induced MPE from BPE. Furthermore, the combined detection of pKL-6\/pADA and pCEA\/pADA can significantly improve the diagnostic efficiency for distinguishing NSCLC-induced MPE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmad076","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T16:14:07Z","timestamp":1691770447000},"page":"271-276","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic value of pleural effusion Krebs von den Lungen-6 in malignant pleural effusion of patients with non\u2013small cell lung cancer"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-2743","authenticated-orcid":false,"given":"Junjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lunan","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"2024050210561994500_CIT0001","first-page":"7","article-title":"Cancer statistics, 2021","volume-title":"CA Cancer J 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