{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:19:06Z","timestamp":1740136746648,"version":"3.37.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Primary biliary cholangitis (PBC) is an autoimmune disease of liver that may be associated with other conditions, including autoimmune thyroid diseases. We aimed to investigate the frequency of anti-thyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and anti\u2013thyrotropin receptor antibodies (TSHR-Ab) in Tunisian patients with PBC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sera of 80 patients with PBC were collected over a 9-year period. A total of 189 healthy blood donors (HBD) were included in the control group. Measurements of TPO-Ab and TG-Ab were performed using indirect enzyme-linked immunosorbent assay (ELISA). Competitive ELISA was used to assess TSHR-Ab.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Antithyroid antibodies (ATA) were significantly more frequent in PBC patients than in the control group (13.7% vs 1.6%; P &amp;lt; 10\u22123). Out of 11 patients with ATA, 10 (90.9%) were female. Nine patients and 2 HBD had TPO-Ab (11.2% vs 1%; P &amp;lt; 10\u22123). TG-Ab were more frequent in patients than in healthy subjects but the difference was not statistically significant (6.2% vs 1.6%; P = .1). TPO-Ab and TG-Ab were present together in 3 patients (3.7%). TSHR-Ab were absent in patients and controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study shows that PBC is associated with a high frequency of ATA but not TG-Ab or TSHR-Ab.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmad080","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:35:57Z","timestamp":1693229757000},"page":"304-309","source":"Crossref","is-referenced-by-count":0,"title":["Frequency of antithyroid antibodies in patients with primary biliary cholangitis"],"prefix":"10.1093","volume":"55","author":[{"given":"Mariam","family":"Ghozzi","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, Farhat Hached University Hospital , Sousse , Tunisia"},{"name":"Faculty of Pharmacy, Department of Immunology, University of Monastir , Monastir , Tunisia"},{"name":"Research Laboratory for 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