{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:54:24Z","timestamp":1776862464010,"version":"3.51.2"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["37688"],"award-info":[{"award-number":["37688"]}]},{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["28984"],"award-info":[{"award-number":["28984"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Increasing mortality and morbidity of coronary artery disease (CAD) highlight the emerging need for novel noninvasive markers such as circulating microRNAs (miRNAs).<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the circulating levels of miR-126-3p, miR-210-3p, let-7g-5p, and miR-326, and their associations with known contributors to CAD, in CAD subgroups.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We divided the cohort into 4 groups: non-CAD controls (\u226430% stenosis; n = 55), and patients with stable angina pectoris (SAP; n = 48), unstable AP (UAP; n = 46), and myocardial infarction (MI; n = 36). The circulating levels of miR-126-3p, miR-210-3p, let-7g-5p, and miR-326 were determined using TaqMan Advanced miRNA Assays in serum specimens.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Circulating miR-126-3p levels were lower in the MI and UAP groups, compared with the non-CAD group, whereas miR-210-3p circulating levels were lower in the MI group than others. The levels of circulating let-7g-5p were shown to be useful for distinguishing UAP from MI, and there were substantial differences in circulating let-7g-5p levels between the UAP and MI groups. Moreover, lipid levels and ratios were lower in individuals with high circulating miR-126-3p and miR-210-3p levels.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The study results suggest that circulating miR-126-3p, miR-210-3p, and let-7g-5p are differentiated between different clinical presentations of CAD and associated with lipid levels, which are important risk factors and determinants of CAD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/labmed\/lmad094","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T23:59:43Z","timestamp":1701734383000},"page":"361-372","source":"Crossref","is-referenced-by-count":9,"title":["Alteration of circulating miRNAs during myocardial infarction and association with lipid levels"],"prefix":"10.1093","volume":"55","author":[{"given":"Aybike Sena","family":"Ozuynuk-Ertugrul","sequence":"first","affiliation":[{"name":"Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University , 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