{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:35:55Z","timestamp":1774647355764,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hashimoto\u2019s thyroiditis (HT) is an autoimmune disease that is frequently associated with other autoimmune conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To perform serological screening for rheumatoid arthritis (RA) in patients with HT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Our study included 88 consecutive serum specimens of patients with confirmed HT and 88 sex- and age-matched healthy subjects. All study participants were tested for anti-cyclic citrullinated peptides antibodies (CCP-Ab) and rheumatoid factor (RF). CCP-Ab and RF were performed using ELISA commercial kits. Statistical analysis was conducted using Epi Info, version 3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 88 patients with HT, 15 (17.0%) had CCP-Ab or RF. The frequency of serological markers of RA was significantly higher in patients than in control individuals (17.0% vs 4.5%; P = .007). RF was more frequent in patients than in the control group, and the difference was statistically significant (13.6% vs 3.4%; P = .01). Isolated RF-IgM was absent in all controls and present in 6 patients with HT (6.8% vs 0%; P = .02). Out of 14 male patients, 3 (21.4%) had antibodies of RA. There was no significant difference in age between patients with CCP-Ab or RF and those without.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A high frequency of serological markers of RA was highlighted in patients with HT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmad100","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T01:45:45Z","timestamp":1701395145000},"page":"433-438","source":"Crossref","is-referenced-by-count":2,"title":["Frequency of serological markers of rheumatoid arthritis in patients with Hashimoto\u2019s thyroiditis"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-6513","authenticated-orcid":false,"given":"Mariam","family":"Ghozzi","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, Farhat Hached University Hospital , Sousse , Tunisia"},{"name":"Faculty of Pharmacy, Department of Immunology, University of Monastir , Monastir , Tunisia"},{"name":"Research Laboratory for Epidemiology and Immunogenetics of Viral Infections (LR14SP02), Sahloul University Hospital, University of Sousse , Sousse , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-689X","authenticated-orcid":false,"given":"Amani","family":"Mankai","sequence":"additional","affiliation":[{"name":"High School of Sciences and Techniques of Health, Tunis El Manar University , Tunis , Tunisia"},{"name":"Research Unit Obesity: Etiopathology and Treatment, UR18ES01, National Institute of Nutrition and Food Technology , Tunis , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-0750","authenticated-orcid":false,"given":"Sarra","family":"Melayah","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Farhat Hached University Hospital , Sousse , Tunisia"},{"name":"Faculty of Pharmacy, Department of Immunology, University of Monastir , Monastir , Tunisia"},{"name":"Research Laboratory LR12SP11, Department of Biochemistry, Sahloul University Hospital , Sousse , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Mechi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Immunology, University of Monastir , Monastir , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeineb","family":"Chedly","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Immunology, University of Monastir , Monastir , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhalim","family":"Trabelsi","sequence":"additional","affiliation":[{"name":"Research Laboratory for Epidemiology and Immunogenetics of Viral Infections (LR14SP02), Sahloul University Hospital, University of Sousse , Sousse , Tunisia"},{"name":"Laboratory of Microbiology and Virology, Sahloul University Hospital, University of Sousse , Sousse , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtissem","family":"Ghedira","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Farhat Hached University Hospital , Sousse , Tunisia"},{"name":"Faculty of Pharmacy, Department of Immunology, University of Monastir , Monastir , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"2024070305531287400_CIT0001","first-page":"918","article-title":"Molecular mechanisms in autoimmune thyroid disease","volume-title":"Cells.","author":"Vargas-Uricoechea","year":"2023"},{"key":"2024070305531287400_CIT0002","first-page":"1801","article-title":"Rheumatic associations of autoimmune thyroid disease: a systematic review","volume-title":"Clin 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