{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:29:41Z","timestamp":1762342181763,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20210004"],"award-info":[{"award-number":["Y20210004"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The noninvasive serum markers pepsinogen I (PGI), pepsinogen II (PGII), gastrin-17 (G17), and PGI:PGII ratio (PGR) have recently been proposed as a new tool for predicting various gastric pathologies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 83 gastritis patients confirmed by gastroscopy were enrolled, with 78 undergoing concurrent colonoscopies. The control group included 99 healthy subjects. Enzyme-linked immunosorbent assay was used to detect PGI, PGII, G17, and PGR. The performance of serological analysis for detecting gastritis pathology was evaluated using receiver operating characteristic (ROC) curves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The G17 and PGII levels increased significantly (P &amp;lt; .001), whereas PGR levels decreased (P = .001) in the gastritis group. The ROC analysis revealed that PGR had a sensitivity and specificity of 70.83% and 86.67%, respectively, in predicting Helicobacter pylori-infected gastritis and a sensitivity and specificity of 88% and 65.52%, respectively, in predicting active gastritis. The G17 levels were significantly elevated in gastritis patients undergoing concurrent colonoscopies (P &amp;lt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pepsinogen I:pepsinogen II ratio was found to be a useful predictor of active gastritis and H pylori-infected gastritis. Furthermore, G17 was found to be closely related to pathological conditions found by colonoscopy and may provide recommendations for whether gastritis patients should undergo a concurrent colonoscopy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmad119","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T09:10:12Z","timestamp":1707469812000},"page":"498-505","source":"Crossref","is-referenced-by-count":3,"title":["The role of gastrin 17 and pepsinogen I:pepsinogen II ratio in pathological diagnosis and endoscopic selection in gastritis patients"],"prefix":"10.1093","volume":"55","author":[{"given":"Qian","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Wenzhou People\u2019s Hospital , Wenzhou, Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Wenzhou People\u2019s Hospital , Wenzhou, Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Wenzhou People\u2019s Hospital , Wenzhou, Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misheng","family":"Zhao,","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Wenzhou People\u2019s Hospital , Wenzhou, Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"issue":"6","key":"2024070305533179500_CIT0001","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3109\/00365521.2015.1019918","article-title":"Chronic gastritis","volume":"50","author":"Sipponen","year":"2015","journal-title":"Scand J 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