{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:36:19Z","timestamp":1791855379020,"version":"4.3.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["1430"],"award-info":[{"award-number":["1430"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Given that obesity and insulin resistance play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the connection between leptin and these metabolic diseases, the association between NAFLD and a leptin receptor gene (LEPR) polymorphism was examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this genetic case-control association study, 144 biopsy-proven NAFLD patients and 144 controls were genotyped for the LEPR gene Gln223Arg (rs1137101) polymorphism using the polymerase chain reaction\u2013restriction fragment length polymorphism method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The distributions of genotypes and alleles of Gln223Arg variant were in accordance with the Hardy-Weinberg equilibrium in the study groups (P &amp;gt; .05). Multivariate logistic regression analysis showed that the LEPR Gln223Arg Arg\/Arg genotype was an independent risk factor for NAFLD; the Arg\/Arg genotype, compared with the Gln\/Gln genotype, was associated with a 2.09-fold increased risk for NAFLD (P = .036, odds ratio = 2.09 [95% CI = 1.31-5.95]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found that the LEPR Gln223Arg Arg\/Arg genotype was independently associated with a more than 2-fold rise in biopsy-proven NAFLD risk. Our findings, however, need to be corroborated by further studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmae016","type":"journal-article","created":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T18:14:47Z","timestamp":1711304087000},"page":"590-594","source":"Crossref","is-referenced-by-count":7,"title":["The Arg\/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease"],"prefix":"10.1093","volume":"55","author":[{"given":"Mahsa","family":"Navari","sequence":"first","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Zarei","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Universit\u00e1 degli Studi di Milano , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Sayedsalehi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touraj","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Rostami","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidin","family":"Mahban","sequence":"additional","affiliation":[{"name":"Department of Business Management, Science and Research Branch, Islamic Azad University , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Rezamand","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences , Tehran , Iran"},{"name":"Colorectal Research Center, Iran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asadollah","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Mohaghegh Ardabili , Ardabil , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dabiri","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Nobakht","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Farahani","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine, Qom University of Medical Sciences , Qom , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-5667","authenticated-orcid":false,"given":"Seidamir Pasha","family":"Tabaeian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences , Tehran , Iran"},{"name":"Colorectal Research Center, Iran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Zali","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"2024090405514484800_CIT0001","first-page":"771","article-title":"The global NAFLD Policy Review and Preparedness Index: are countries ready to address this silent public health challenge","volume-title":"J Hepatol.","author":"Lazarus","year":"2022"},{"key":"2024090405514484800_CIT0002","first-page":"e7041","article-title":"Triglyceride glucose-body mass index is effective in identifying nonalcoholic fatty liver disease in nonobese subjects","volume-title":"Medicine 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