{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:19:02Z","timestamp":1740136742723,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5T35 AI 078878-13"],"award-info":[{"award-number":["5T35 AI 078878-13"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Non\u2013small cell lung cancer (NSCLC) has been found to have recurrent genetic abnormalities, and novel therapies targeting these aberrations have improved patient survival. In this study, specimens from benign tissue, primary tumors, and brain metastases were obtained at autopsy from a 55-year-old White female patient diagnosed with NSCLC and were examined using next-generation sequencing (NGS) and chromosomal microarray assay (CMA). No genetic aberrations were noted in the benign tissue; however, NGS identified a mutation in the KRAS proto-oncogene, GTPase (KRAS): KRAS exon 2 p.G12D in primary and metastatic tumor specimens. We observed 7 DNA copy number aberrations (CNAs) in primary and metastatic tumor specimens; an additional 7 CNAs were exclusively detected in the metastatic tumor specimens. These DNA alterations may be genetic drivers in the pathogenesis of the tumor specimen from our patient and may serve as biomarkers for the classification and prognosis of NSCLC.<\/jats:p>","DOI":"10.1093\/labmed\/lmae019","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T19:51:57Z","timestamp":1711396317000},"page":"658-662","source":"Crossref","is-referenced-by-count":0,"title":["DNA variants detected in primary and metastatic lung adenocarcinoma: a case report and review of the literature"],"prefix":"10.1093","volume":"55","author":[{"given":"Christina","family":"Kelly","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine, University of Texas Medical Branch , Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-1996","authenticated-orcid":false,"given":"Caitlin","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youmin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyijia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-6132","authenticated-orcid":false,"given":"Jianli","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"2024090405514575400_CIT0001","first-page":"17","article-title":"Cancer statistics, 2023","volume-title":"CA Cancer J Clin.","author":"Siegel","year":"2023"},{"key":"2024090405514575400_CIT0002","first-page":"1259","article-title":"Clinicopathological characteristics and mutations driving development of early lung adenocarcinoma: tumor initiation and progression","volume-title":"Int J Mol Sci.","author":"Inamura","year":"2018"},{"key":"2024090405514575400_CIT0003","first-page":"543","article-title":"Comprehensive molecular profiling of lung 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(Basel)","author":"O\u2019Sullivan","year":"2023"},{"key":"2024090405514575400_CIT0016","first-page":"556","article-title":"Comprehensive profiling of gene copy number alterations predicts patient prognosis in resected stages I-III lung adenocarcinoma","volume-title":"Front Oncol.","author":"Han","year":"2019"}],"container-title":["Laboratory 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