{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T16:48:48Z","timestamp":1749746928538,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005946","name":"Hokkaido University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lipids interfere with absorbance measurements conducted using colorimetric methods. To monitor lipemia, some systems measure absorbance using an analyzer. This report describes a novel case of interference with the lipemia index without lipemia. A 64-year-old woman with giant basal cell carcinoma underwent resection and sentinel lymph node biopsy. The patient had been subcutaneously injected with patent blue during sentinel lymph node resection. After surgery, her serum and urine were yellow-green, and the lipemia index, calculated by measuring absorbance at 658 nm (main wavelength) and 694 nm (secondary wavelength) using a JCA-BM8040 chemistry analyzer, was high. The absorbance spectrum of the patient\u2019s serum and patent blue solution were compared to determine the cause of the high lipemia index. The patient\u2019s serum and the patent blue solution showed absorption at wavelengths between 540 and 698 nm. Moreover, the absorbance was concentration-dependent for patent blue. These results thus indicated that the patient\u2019s serum contained patent blue. Here, we report a case wherein patent blue affected the lipemia index. Thus, it must be noted that patent blue injection may yield inaccurate results when evaluating lipemia index.<\/jats:p>","DOI":"10.1093\/labmed\/lmae028","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:47:16Z","timestamp":1713178036000},"page":"672-675","source":"Crossref","is-referenced-by-count":1,"title":["Patent blue interferes with the measurement of lipemia index in a patient with sentinel lymph node"],"prefix":"10.1093","volume":"55","author":[{"given":"Keiichi","family":"Nakano","sequence":"first","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital , Sapporo , Japan"},{"name":"Department of Medical Technology and Sciences, School of Health Sciences at Narita, International University of Health and Welfare , Chiba , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Seimiya","sequence":"additional","affiliation":[{"name":"Department of Medical Technology and Sciences, School of Health Sciences at Narita, International University of Health and Welfare , Chiba , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hokkaido University Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-271X","authenticated-orcid":false,"given":"Takanori","family":"Teshima","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"2024090405514919000_CIT0001","first-page":"459","article-title":"Establishing hemolysis and lipemia acceptance thresholds for clinical chemistry tests","volume-title":"Clin Chim Acta.","author":"Knezevic","year":"2020"},{"key":"2024090405514919000_CIT0002","first-page":"1442","article-title":"Binding of nitric oxide to thiols and hemes in hemoglobin H: implications for alpha-thalassemia and hypertension","volume-title":"Clin Chem.","author":"Reddy","year":"1997"},{"key":"2024090405514919000_CIT0003","first-page":"54","article-title":"The effect of hematocrit on the efficacy of phototherapy for neonatal jaundice","volume-title":"Pediatr Res.","author":"Lamola","year":"2013"},{"key":"2024090405514919000_CIT0004","first-page":"345","article-title":"Interference by haemolysis, icterus and lipaemia in assays on the Beckman Synchron CX5 and methods for correction","volume-title":"Ann Clin Biochem.","author":"Randall","year":"1990"},{"key":"2024090405514919000_CIT0005","first-page":"31","article-title":"The influence of bilirubin, haemolysis and turbidity on 20 analytical tests performed on automatic analysers: results of an interlaboratory study","volume-title":"Eur J Clin Chem Clin Biochem.","author":"Grafmeyer","year":"1995"},{"key":"2024090405514919000_CIT0006","first-page":"357","article-title":"The haemolytic, icteric and lipemic sample recommendations regarding their recognition and prevention of clinically relevant interferences: recommendations of the working group on preanalytical variables of the German Society for Clinical Chemistry and the German Society for Laboratory Medicine","volume-title":"LaboratoriumsMedizin.","author":"Guder","year":"2000"},{"key":"2024090405514919000_CIT0007","first-page":"527","article-title":"Serum indices: managing assay interference","volume-title":"Ann Clin Biochem.","author":"Farrell","year":"2016"},{"key":"2024090405514919000_CIT0008","first-page":"893","article-title":"A retrospective analysis of rates of allergic reaction to patent V blue dye used in sentinel lymph node biopsies for melanoma","volume-title":"J Plast Reconstr Aesthet Surg.","author":"Manton","year":"2022"},{"key":"2024090405514919000_CIT0009","article-title":"CLSI Document c56-A","volume-title":"Hemolysis, Icterus, and Lipemia\/Turbidity Indices as Indicators of Interference in Clinical Laboratory Analysis; Approved Guideline.","author":"CLS Institute","year":"2012"},{"key":"2024090405514919000_CIT0010","first-page":"e00232","article-title":"Optimization of hemolysis, icterus and lipemia interference thresholds for 35 clinical chemistry assays","volume-title":"Pract Lab Med.","author":"Ho","year":"2021"},{"key":"2024090405514919000_CIT0011","first-page":"57","article-title":"Lipemia: causes, interference mechanisms, detection and management","volume-title":"Biochem Med (Zagreb)","author":"Nikolac","year":"2014"},{"key":"2024090405514919000_CIT0012","first-page":"289","article-title":"Interference with serum indices measurement, but not chemical analysis, on the Roche Modular by patent blue V","volume-title":"Ann Clin Biochem.","author":"Darby","year":"2008"},{"key":"2024090405514919000_CIT0013","first-page":"2600","article-title":"Sentinel lymph node mapping with patent blue dye in patients with breast cancer: a retrospective single institution study","volume-title":"Gland Surg","author":"Olivier","year":"2021"},{"key":"2024090405514919000_CIT0014","first-page":"497","article-title":"Anaphylaxis to isosulfan blue and cross-reactivity to patent blue V: case report and review of the nomenclature of vital blue dyes","volume-title":"Ann Allergy Asthma Immunol.","author":"Scherer","year":"2006"},{"key":"2024090405514919000_CIT0015","first-page":"53","article-title":"The influence of patent blue V on pulse oximetry and haemoximetry","volume-title":"Acta Anaesthesiol Scand Suppl.","author":"Larsen","year":"1995"},{"key":"2024090405514919000_CIT0016","first-page":"63","article-title":"Hemoadsorption to treat severe iatrogenic intoxication with patent blue: a case report","volume-title":"J Med Case Rep.","author":"Taccone","year":"2021"}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/55\/5\/672\/58985590\/lmae028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/55\/5\/672\/58985590\/lmae028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T23:34:02Z","timestamp":1725492842000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/55\/5\/672\/7645773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,4,15]]},"published-print":{"date-parts":[[2024,9,4]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmae028","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"type":"print","value":"0007-5027"},{"type":"electronic","value":"1943-7730"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,4,15]]}}}