{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:47Z","timestamp":1787009207171,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The ratio of \u03b3-glutamyl transferase to HDL-C (GGT\/HDL-C) has been proposed as a discriminator of metabolic syndrome. The purpose of this study was to elucidate the relationship between GGT\/HDL-C and glycemic status in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The subjects were 18,218 middle-aged women who had received annual health checkups in their workplaces. They were divided by habitual alcohol intake into nondrinkers, occasional drinkers, regular light drinkers, and regular heavy drinkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In overall subjects, hemoglobin A1c level and prevalence of diabetes tended to be higher in subjects with higher GGT\/HDL-C, and GGT\/HDL-C tended to be higher with an increase of alcohol intake. The odds ratio for hyperglycemia in subjects with vs. subjects without high GGT\/HDL-C tended to be lower with an increase of alcohol intake, and the association between high GGT\/HDL-C and hyperglycemia was significantly weaker in regular heavy drinkers than in nondrinkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In middle-aged women, there were positive associations of GGT\/HDL-C with alcohol intake and glycemic status, and the association between GGT\/HDL-C and glycemic status tended to be weaker with an increase of alcohol intake. Thus, alcohol use should be taken into account when GGT\/HDL-C is used as a discriminator of diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmae084","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T07:19:11Z","timestamp":1728285551000},"page":"230-237","source":"Crossref","is-referenced-by-count":2,"title":["Associations between glycemic status and the ratio of \u03b3-glutamyl transferase to HDL-C in middle-aged women"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6142-9976","authenticated-orcid":false,"given":"Ichiro","family":"Wakabayashi","sequence":"first","affiliation":[{"name":"Department of Environmental and Preventive Medicine, School of Medicine, Hyogo Medical University , Nishinomiya, Hyogo 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