{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:09:23Z","timestamp":1753877363236,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172336"],"award-info":[{"award-number":["82172336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Research & Development Program of Jiangsu Province","award":["BE2020637"],"award-info":[{"award-number":["BE2020637"]}]},{"name":"the Key Research and Development Project of Zhejiang Province","award":["2022C03118"],"award-info":[{"award-number":["2022C03118"]}]},{"name":"the Key Research and Development Project of Hangzhou","award":["202004A23"],"award-info":[{"award-number":["202004A23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Regenerating protein I alpha (REG I\u03b1) plays a key role in the progression of gastric cancer (GC). However, the clinical application value of serum REG I\u03b1 in GC remains largely unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Serum REG I\u03b1 levels were analyzed through time-resolved fluoroimmunoassay (TRFIA) in healthy controls (HCs) and patients with benign gastric disease (BGD) and GC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The REG I\u03b1 levels of patients with GC were significantly higher than those of HCs and patients with BGD (P &amp;lt; .0001). The REG I\u03b1 levels were higher in patients with GC with poor pathological differentiation type; tumor, node, and metastasis stages III-IV; deep tumor invasion (T3\u2013T4); and distant metastasis (P &amp;lt; .05). The diagnostic efficiency of the combined REG I\u03b1, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) tests improved compared with that of the single-indicator test for the diagnosis of patients with GC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>REG I\u03b1-TRFIA may facilitate the ancillary diagnosis of GC and have a monitoring role for further progression of GC. It can also help elucidate the possible diagnostic role of serum REG I\u03b1 as a noninvasive tool.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmae106","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T23:10:31Z","timestamp":1736723431000},"page":"375-383","source":"Crossref","is-referenced-by-count":0,"title":["Serologic detection of regenerating protein I alpha by time-resolved fluoroimmunoassay and its clinical value in gastric cancer"],"prefix":"10.1093","volume":"56","author":[{"given":"Zhongyi","family":"Xiang","sequence":"first","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Xiaoshan Hospital, Hangzhou Normal University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akao","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqin","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongming","family":"Fang","sequence":"additional","affiliation":[{"name":"Affiliated Xiaoshan Hospital, Hangzhou Normal University , Hangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[{"name":"The Jiangyin Clinical College of Xuzhou Medical University , Jiangyin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"2025071202514693000_CIT0001","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/S0021-9258(18)69176-8","article-title":"A novel gene activated in regenerating islets","volume":"263","author":"Terazono","year":"1988","journal-title":"J Biol Chem."},{"key":"2025071202514693000_CIT0002","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1016\/S0021-9258(19)39132-X","article-title":"Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. 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