{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:37:30Z","timestamp":1757623050981,"version":"3.44.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Nature Science Foundation Program of Cangzhou","award":["23241001012N"],"award-info":[{"award-number":["23241001012N"]}]},{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["2024-2"],"award-info":[{"award-number":["2024-2"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Severe acute pancreatitis is a life-threatening condition characterized by systemic inflammatory response syndrome and an increased risk of complications such as venous thrombosis, all of which contributes to a high mortality rate. Heparin resistance, although rare, can lead to ineffective anticoagulation and thrombus formation during unfractionated heparin therapy, complicating management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We report a case of heparin resistance in which, despite increasing the unfractionated heparin dosage, the patient\u2019s activated partial thromboplastin time remained subtherapeutic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Laboratory findings indicated normal antithrombin levels but undetectable anti-Xa activity, confirming non\u2013antithrombin-mediated heparin resistance. A multidisciplinary approach led to the successful management of thrombosis with rivaroxaban, resulting in substantial clinical improvement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case highlights the importance of early recognition and management of heparin resistance in patients with severe acute pancreatitis. Combined monitoring of activated partial thromboplastin time and anti-Xa activity is crucial for optimizing anticoagulation therapy and preventing complications such as deep vein thrombosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmae126","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T10:39:16Z","timestamp":1744799956000},"page":"570-576","source":"Crossref","is-referenced-by-count":0,"title":["Heparin resistance in a patient with severe acute pancreatitis: a case report"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8241-3266","authenticated-orcid":false,"given":"Dai","family":"Rongqin","sequence":"first","affiliation":[{"name":"Department of Medical Technology, Cangzhou Medical College , Cangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai","family":"Zhexin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yuzhi","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Cangzhou Medical College , Cangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Zhenbin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnosis, Cangzhou Hospital of Integrated Chinese and Western Medicine , Cangzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Jinbiao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnosis, Cangzhou Hospital of Integrated Chinese and Western Medicine , Cangzhou 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