{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T13:26:02Z","timestamp":1763817962313,"version":"3.45.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Aneuploidies are commonly implicated in spontaneous abortions. Trisomy with concurrent monosomy of chromosome X is a rare finding that may mimic hydatidiform mole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe a case of trisomy 15 and monosomy X in a product of conception. Ultrasound revealed a gestation with absent cardiac activity; pregnancy was terminated by dilation and curettage at 11 weeks, 6 days. Histopathologic examination and cytogenetic analysis were performed on the products of conception to identify the cause of pregnancy loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chromosome microarray revealed a chromosome complement with trisomy 15 and monosomy X, [arr(X)\u00d71, (15)\u00d73], consistent with a karyotype of 46,X +15.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Histopathologic examination of products of conception with aneuploidies may be inconclusive, and chromosomal microarray is a versatile tool in these scenarios to rule out clinically significant entities such as hydatidiform mole. An imbalance of imprinted gene dosage from chromosome 15 may contribute to the histopathologic findings in this case.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmaf050","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:11:06Z","timestamp":1752747066000},"page":"819-823","source":"Crossref","is-referenced-by-count":0,"title":["Trisomy 15 and monosomy X in a product of conception: a case report"],"prefix":"10.1093","volume":"56","author":[{"given":"Joshua","family":"Fernandez de la Vega","sequence":"first","affiliation":[{"name":"Department of Pathology, John Sealy School of Medicine , Galveston, Texas ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arian","family":"Pourmehdi Lahiji","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, Texas ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, Texas ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, Texas ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-6132","authenticated-orcid":false,"given":"Jianli","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, Texas ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshwardhan M","family":"Thaker","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch , Galveston, Texas ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"2025112208222373000_CIT0001","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.ogc.2022.04.004","article-title":"First trimester miscarriage","volume":"49","author":"Shaker","year":"2022","journal-title":"Obstet Gynecol Clin North Am."},{"key":"2025112208222373000_CIT0002","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/gim.2016.69","article-title":"Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges","volume":"19","author":"Sahoo","year":"2017","journal-title":"Genet Med."},{"key":"2025112208222373000_CIT0003","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/jmg.35.11.924","article-title":"Studies of non-disjunction in trisomies 2, 7, 15, and 22: does the parental origin of trisomy influence placental morphology","volume":"35","author":"Zaragoza","year":"1998","journal-title":"J Med Genet."},{"key":"2025112208222373000_CIT0004","doi-asserted-by":"publisher","first-page":"S111","DOI":"10.1053\/plac.2002.0939","article-title":"Genomic imprinting in gestational trophoblastic disease--a review","volume":"24","author":"Fisher","year":"2003","journal-title":"Placenta."},{"key":"2025112208222373000_CIT0005","doi-asserted-by":"publisher","first-page":"S152","DOI":"10.1016\/j.ajog.2015.06.032","article-title":"Genomic imprinting in the human placenta","volume":"213","author":"Monk","year":"2015","journal-title":"Am J Obstet Gynecol."},{"key":"2025112208222373000_CIT0006","doi-asserted-by":"crossref","first-page":"e262","DOI":"10.1097\/AOG.0000000000001817","article-title":"Committee Opinion No.682: Microarrays and next-generation sequencing technology: the use of advanced genetic diagnostic tools in obstetrics and gynecology","volume":"128","author":"Vora","year":"2016","journal-title":"Obstet Gynecol."},{"key":"2025112208222373000_CIT0007","doi-asserted-by":"publisher","first-page":"B2","DOI":"10.1016\/j.ajog.2016.07.016","article-title":"The use of chromosomal microarray for prenatal diagnosis","volume":"215","author":"Dugoff","year":"2016","journal-title":"Am J Obstet Gynecol."},{"key":"2025112208222373000_CIT0008","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/OGX.0000000000000119","article-title":"Chromosomal microarray analysis and prenatal diagnosis","volume":"69","author":"Lo","year":"2014","journal-title":"Obstet Gynecol Surv."},{"key":"2025112208222373000_CIT0009","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/labmed\/lmad052","article-title":"The first reported case of double trisomy 10 and 20 in a product of conception","volume":"55","author":"Fernandez De La Vega","year":"2023","journal-title":"Lab. 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