{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:32:08Z","timestamp":1769070728336,"version":"3.49.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Laboratory tests play a crucial role in diagnosing and managing illness. Accurate interpretation, which includes evaluating false-negative and false-positive results, is essential for guiding appropriate clinical interventions and ensuring patient safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present a case involving clinically significant discrepancies in lactate measurements in a patient with acute myeloid leukemia and diabetic ketoacidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These discrepancies were caused by interference from elevated levels of ketone bodies\u2014specifically, \u03b2-hydroxybutyrate\u2014which may have delayed recognition of the severity of the patient\u2019s condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Dilution and spike experiments suggested potential interferences in core laboratory instruments using the Trinder reaction, leading to inaccurate lactate readings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmaf061","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T11:43:28Z","timestamp":1756640608000},"source":"Crossref","is-referenced-by-count":0,"title":["A falsely low lactate: discrepancies in lactate measurement between blood gas and core laboratory instruments due to \u03b2-hydroxybutyrate interference\u2014a case report"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3736-0300","authenticated-orcid":false,"given":"Nadia M","family":"Alqurini","sequence":"first","affiliation":[{"name":"Department of Nephrology, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawana","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-4596","authenticated-orcid":false,"given":"Hoda A","family":"Hagrass","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"2026012111465368100_CIT0001","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13049-015-0151-x","article-title":"The accuracy and timeliness of a point of care lactate measurement in patients with sepsis","volume":"23","author":"Ismail","year":"2015","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"2026012111465368100_CIT0002","doi-asserted-by":"publisher","first-page":"e66356","DOI":"10.7759\/cureus.66356","article-title":"Lactate monitoring in intensive care: a comprehensive review of its utility and interpretation","volume":"16","author":"Deulkar","year":"2024","journal-title":"Cureus"},{"key":"2026012111465368100_CIT0003","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1177\/000456326900600108","article-title":"Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor","volume":"6","author":"Trinder","year":"1969","journal-title":"Ann. 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