{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:04:50Z","timestamp":1775919890621,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Istanbul University Scientific Research Projects Unit","award":["TTU-2022\u201338859"],"award-info":[{"award-number":["TTU-2022\u201338859"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bladder cancer is prevalent worldwide; however, the detailed mechanisms underlying its initiation and progression remain incompletely understood. This study aimed to investigate the expression levels of long noncoding RNA activated by transforming growth factor-\u03b2 (lncRNA-ATB) and microRNA-200c (miR-200c) in tumor tissues of patients with bladder cancer and to explore their association with clinicopathologic features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study cohort consisted of 50 patients diagnosed with non\u2013muscle-invasive bladder cancer. Tumor tissues and adjacent normal tissues were obtained during transurethral resection of bladder tumor. The relative expression levels of lncRNA-ATB and miR-200c were determined using quantitative reverse transcriptase\u2013polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LncRNA-ATB expression was substantially higher in tumor tissues than in adjacent normal tissues. Conversely, miR-200c was upregulated in tumor tissues but showed lower expression in high-grade tumors compared with low-grade tumors. A receiver operating characteristic curve analysis indicated that lncRNA-ATB (72% sensitivity, 68% specificity) and miR-200c (68% sensitivity, 64% specificity) could distinguish tumor from normal tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study is the first to concurrently evaluate lncRNA-ATB and miR-200c expression in non\u2013muscle-invasive bladder cancer. Even in early-stage bladder cancer, alterations in the lncATB\/miR-200c axis appear to be associated with tumor grade and may potentially serve as an indicator of metastatic potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag011","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:48:14Z","timestamp":1772628494000},"source":"Crossref","is-referenced-by-count":0,"title":["Expression of lncRNA-ATB and miR-200c in patients with bladder cancer: a pilot study"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-8285","authenticated-orcid":false,"given":"Murat","family":"Kaytaz","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Bogazliyan State Hospital , Yozgat,","place":["Turkey"]},{"name":"Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Enes","family":"Degirmenci","sequence":"additional","affiliation":[{"name":"Department of Urology, Florence Nightingale Hospital , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Kucukgergin","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdurrahman Fatih","family":"Aydin","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oner","family":"Sanli","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Urology, Istanbul University , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Erdem","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Urology, Istanbul University , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faruk","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Urology, Istanbul University , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Ozluk","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Pathology, Istanbul University , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra","family":"Dogru Abbasoglu","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University , 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