{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:14:00Z","timestamp":1779293640911,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Giresun University","award":["SA\u011e-BAP-A-270220-17"],"award-info":[{"award-number":["SA\u011e-BAP-A-270220-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>ATP2B1 and STK39 loci influence blood pressure in genome-wide association studies. We tested whether ATP2B1 rs2681472 and STK39 rs35929607 are associated with essential hypertension and blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 194 untreated hypertensive adults and 191 normotensive control individuals. Genotypes were determined by polymerase chain reaction\u2013restriction fragment length polymorphism. Logistic regression evaluated hypertension risk, and linear regression assessed systolic and diastolic blood pressure (BP) under genotypic, dominant, and additive models, with adjustment for clinical covariates; the false discovery rate was controlled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The STK39 rs35929607 G allele was associated with hypertension (adjusted odds ratio [OR], 1.97 [95% CI, 1.21-3.21]; P\u2009=\u2009.007) and higher systolic BP (+8.02\u2009mm\u2009Hg per G allele, 95% CI, 2.18-13.87; P\u2009=\u2009.007). Effects on diastolic BP were weaker (additive P\u2009=\u2009.10; dominant P\u2009=\u2009.06). ATP2B1 rs2681472 showed no statistically significant associations (hypertension per T allele OR, 1.18 [95% CI, 0.74-1.87]; P\u2009=\u2009.49). In sex-stratified analyses, STK39 associations were evident in men (hypertension OR, 3.22 [95% CI, 1.42-7.31]; P\u2009=\u2009.005; systolic BP, +15.88\u2009mm\u2009Hg [95% CI, 5.95-25.80]; P\u2009=\u2009.002) but not in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In our study cohort, STK39 rs35929607 is associated with essential hypertension and higher systolic BP, with possible sex-specific effects. ATP2B1 rs2681472 is not associated with hypertension or BP traits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag025","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T11:34:17Z","timestamp":1774784057000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of\n                    <i>ATP2B1<\/i>\n                    and\n                    <i>STK39<\/i>\n                    gene variants with blood pressure levels in patients with essential hypertension"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1979-419X","authenticated-orcid":false,"given":"Egemen","family":"Akg\u00fcn","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Giresun University , Giresun,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-1276","authenticated-orcid":false,"given":"Ahmet","family":"Karag\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Samsun University , Samsun,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-9420","authenticated-orcid":false,"given":"Fadime","family":"Mutlu \u0130\u00e7duygu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, Giresun University , Giresun,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7303-666X","authenticated-orcid":false,"given":"Ebru","family":"Alp","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Giresun University , 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