{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:54:14Z","timestamp":1781502854444,"version":"3.54.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Symptomatic hypocalcemia and hypomagnesemia are life-threatening emergencies. Acute diagnostic and therapeutic maneuvers are well known, but underlying etiologies and the long-term therapeutic choices are not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 38-year-old woman who was found to have metastatic malignant melanoma during post\u2013iodide 131 treatment uptake and whole-body scanning for treatment of differentiated thyroid cancer presented to an emergency department after the third round of platinum-based chemotherapy with severe muscle cramping. She was found to have profound hypocalcemia that was treated. The next day, her symptoms returned, and severe hypomagnesemia was found in a visit with her oncologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Blood and urine tests revealed severe renal magnesium wasting and inappropriately normal intact parathyroid hormone given her severe hypocalcemia. All electrolyte abnormalities resolved with intravenous magnesium administration over 2 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Severe renal magnesium wasting can cause concurrent functional hypoparathyroidism. Recognition of concurrent hypomagnesemia is essential in the laboratory workup of hypocalcemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag035","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:06:15Z","timestamp":1778760375000},"source":"Crossref","is-referenced-by-count":0,"title":["Renal magnesium wasting and functional hypoparathyroidism: a diagnostic and therapeutic challenge in hypocalcemia"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4060-2252","authenticated-orcid":false,"given":"Amnon","family":"Schlegel","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Spencer Fox Eccles School of Medicine, University of Utah , Salt Lake City, UT,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"2026061501161409900_lmag035-B1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-3-319-60167-0_24","volume-title":"Fluid, Electrolyte and Acid-Base Disorders: Clinical Evaluation and Management","author":"Reddi","year":"2018","edition":"2nd"},{"key":"2026061501161409900_lmag035-B2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.4158\/EP10302.RA","article-title":"Medical management of postsurgical hypoparathyroidism","volume":"17 Suppl 1","author":"Khan","year":"2011","journal-title":"Endocr Pract"},{"key":"2026061501161409900_lmag035-B3","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1056\/NEJM199103143241103","article-title":"Transient hypoparathyroidism during acute alcohol intoxication","volume":"324","author":"Laitinen","year":"1991","journal-title":"New Engl J Med"},{"key":"2026061501161409900_lmag035-B4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.clinbiochem.2021.03.016","article-title":"Automatic reflex addition of serum magnesium determination to samples with severe hypocalcemia is an effective tool to detect and treat hypomagnesemia","volume":"92","author":"Pasqualetti","year":"2021","journal-title":"Clin Biochem"},{"key":"2026061501161409900_lmag035-B5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/labmed\/lmab030","article-title":"Stat laboratory interventions to improve patient management in the emergency department and resource expenditures: a 10-year study","volume":"53","author":"Salinas","year":"2022","journal-title":"Lab Med"},{"key":"2026061501161409900_lmag035-B6","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/s0272-6386(12)80667-6","article-title":"Magnesium deficiency: pathophysiologic and clinical overview","volume":"24","author":"Al-Ghamdi","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"2026061501161409900_lmag035-B7","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1365-2265.1976.tb01947.x","article-title":"Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency","volume":"5","author":"Rude","year":"1976","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/57\/4\/lmag035\/68524466\/lmag035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/57\/4\/lmag035\/68524466\/lmag035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:16:17Z","timestamp":1781500577000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/doi\/10.1093\/labmed\/lmag035\/8707831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6,10]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmag035","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,6,10]]},"article-number":"lmag035"}}