{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:54:17Z","timestamp":1781502857070,"version":"3.54.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Key Research and Development Programme Project of Liaoning Provincial Department of Science and Technology","award":["2021JH2-10300045"],"award-info":[{"award-number":["2021JH2-10300045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis. Hyperleukocytosis in pertussis contributes to a drastically worsened prognosis by promoting pulmonary hypertension and multiorgan failure, leading to accelerated disease progression and elevated mortality. Exchange transfusion can improve the prognosis of in children with pertussis and increase the success rate of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 2 infants with severe pertussis treated with modified exchange transfusion. Reconstituted whole blood was prepared using O-type leukoreduced concentrated red blood cells and AB-type leukocyte-reduced, virus-inactivated fresh frozen plasma, with a red blood cell to plasma ratio of 1:1 to 2:1 and a hematocrit of 40% to 50%. The total exchange volume was 150 to 180\u2009mL\/kg (approximately twice the blood volume).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After exchange transfusion, both infants showed marked reduction in white blood cell count and clinically significant improvement in dyspnea. No severe adverse reactions occurred, and both children were discharged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Modified double-volume exchange transfusion is a safe and effective treatment for infants with severe pertussis and hyperleukocytosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag036","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:38:22Z","timestamp":1779190702000},"source":"Crossref","is-referenced-by-count":0,"title":["Modified double-volume exchange transfusion in 2 infants with severe pertussis and hyperleukocytosis"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6717-3973","authenticated-orcid":false,"given":"Si-Meng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8589-5963","authenticated-orcid":false,"given":"Qiu-Shi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"2026061501161678400_lmag036-B1","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1186\/s12889-020-09303-2","article-title":"Pertussis outbreak in southern Ethiopia: challenges of detection, management, and response","volume":"20","author":"Mitiku","year":"2020","journal-title":"BMC Public Health"},{"key":"2026061501161678400_lmag036-B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2807\/1560-7917.ES.2024.29.23.2400301","article-title":"Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies","volume":"29","author":"Poeta","year":"2024","journal-title":"Eurosurveillance"},{"key":"2026061501161678400_lmag036-B3","doi-asserted-by":"publisher","first-page":"116225","DOI":"10.1016\/j.diagmicrobio.2024.116225","article-title":"Pertussis outbreak in children hospitalized in Rabat (Morocco)","volume":"109","author":"Bennai","year":"2024","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2026061501161678400_lmag036-B4","doi-asserted-by":"publisher","first-page":"e166","DOI":"10.1017\/S0950268823001577","article-title":"Pertussis outbreak mainly in unvaccinated young children in ultra-orthodox Jewish groups, Jerusalem, Israel 2023","volume":"151","author":"Stein-Zamir","year":"2023","journal-title":"Epidemiol Infect"},{"key":"2026061501161678400_lmag036-B5","doi-asserted-by":"publisher","first-page":"e2014059","DOI":"10.4084\/MJHID.2014.059","article-title":"Predictors of mortality in mechanically ventilated critical pertussis in a low income country: new resurgence in 2013","volume":"6","author":"Borgi","year":"2014","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"2026061501161678400_lmag036-B6","doi-asserted-by":"publisher","first-page":"e074","DOI":"10.5001\/omj.2014.65","article-title":"Severe pertussis pneumonia managed with exchange transfusion","volume":"29","author":"Al Hanshi","year":"2014","journal-title":"Oman Med J"},{"key":"2026061501161678400_lmag036-B7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12887-021-02507-4","article-title":"Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Pediatr"},{"key":"2026061501161678400_lmag036-B8","doi-asserted-by":"publisher","first-page":"ftw087","DOI":"10.1093\/femspd\/ftw087","article-title":"Pertussis leukocytosis: mechanisms, clinical relevance and 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