{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:00:23Z","timestamp":1790434823705,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302601"],"award-info":[{"award-number":["82302601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inconsistent results among platelet function assays complicate clinical interpretation. This study evaluated clinical agreement among light transmission aggregometry (LTA), thromboelastography (TEG)-platelet mapping, and the INNOVANCE Platelet Function Analyzer 200 system across diverse clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Platelet function assays were performed in 3 cohorts, generating 4 datasets: 22 patients with aneurysm who were on dual antiplatelet therapy, 20 pregnant women on aspirin monotherapy, and 21 patients with an intracranial space\u2013occupying lesion not on antiplatelet therapy allocated to a preoperative or postoperative cohort as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For the cyclooxygenase 1 pathway, no statistically significant correlations were found among any assay pairs in any dataset. For the adenosine diphosphate pathway, statistically significant correlations were observed only in dataset 1 between LTA and TEG (r\u2009=\u2009\u20120.80, 95% CI\u2009=\u2009\u20120.91 to \u20120.55; P\u2009&amp;lt;\u2009.001) and between PFA-200 and TEG (r\u2009=\u20090.44, 95%CI = 0.009 to 0.73; P\u2009=\u2009.04). In dataset 2, detection rates of aspirin responsiveness of PFA-200 (30%) were lower than with LTA (95%) and TEG (100%) (P\u2009&amp;lt;\u2009.001). In dataset 4, detection rates of platelet hyporesponsiveness (adenosine diphosphate pathway) were 61.9% (LTA), 100% (TEG), and 4.8% (PFA-200), with all pairwise comparisons statistically significantly different (P\u2009&amp;lt;\u2009.001). No statistically significant differences among assays were observed in other comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>No single assay can be recommended over the others. Assay selection should be guided by the specific clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag067","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:36:11Z","timestamp":1787657771000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlation and categorical discrepancies of platelet function assays across diverse clinical settings: an exploratory analysis"],"prefix":"10.1093","volume":"57","author":[{"given":"Liqin","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaonan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunbei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-9068","authenticated-orcid":false,"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"2026092610333309100_lmag067-B1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"van der Meijden","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2026092610333309100_lmag067-B2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1080\/09674845.2016.1156865","article-title":"Platelet function testing: from routine to specialist testing","volume":"73","author":"Gurney","year":"2016","journal-title":"Br J Biomed Sci"},{"key":"2026092610333309100_lmag067-B3","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1055\/s-0042-1757898","article-title":"Platelet function testing: update and future directions","volume":"49","author":"Larsen","year":"2023","journal-title":"Semin Thromb Hemost"},{"key":"2026092610333309100_lmag067-B4","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1515\/cclm-2022-0666","article-title":"Towards 50 years of platelet function analyser (PFA) testing","volume":"61","author":"Favaloro","year":"2022","journal-title":"Clin Chem Lab Med"},{"key":"2026092610333309100_lmag067-B5","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1093\/eurheartj\/ehm226","article-title":"A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease","volume":"28","author":"Lordkipanidz\u00e9","year":"2007","journal-title":"Eur Heart J"},{"key":"2026092610333309100_lmag067-B6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jocn.2020.06.004","article-title":"A comparison of three platelet function tests in ischemic stroke patients with antiplatelet therapy","volume":"78","author":"Shao","year":"2020","journal-title":"J Clin Neurosci"},{"key":"2026092610333309100_lmag067-B7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1515\/cclm-2020-0737","article-title":"Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100\u00ae in patients undergoing neuroendovascular procedures","volume":"59","author":"Rolling","year":"2020","journal-title":"Clin Chem Lab Med"},{"key":"2026092610333309100_lmag067-B8","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.3390\/ijms25052997","article-title":"Study on the mechanism of the adrenaline-evoked procoagulant response in human platelets","volume":"25","author":"Go\u0142aszewska","year":"2024","journal-title":"IJMS"},{"key":"2026092610333309100_lmag067-B9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3109\/09537109409005526","article-title":"Investigations on spontaneous aggregation and platelet responses to streptokinase and to adrenaline during pregnancy","volume":"5","author":"Fox","year":"1994","journal-title":"Platelets"},{"key":"2026092610333309100_lmag067-B10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jtha.2025.09.018","article-title":"Effects of physical activity on platelet activation and hemostasis during pregnancy - are placento-exerkines the hidden drivers?","volume":"24","author":"Lyssy","year":"2026","journal-title":"J Thromb Haemost"},{"key":"2026092610333309100_lmag067-B11","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1080\/09537104.2018.1478402","article-title":"Comparison of nine platelet function tests used to determine responses to different aspirin dosages in people with type 2 diabetes","volume":"30","author":"Harrison","year":"2019","journal-title":"Platelets"},{"key":"2026092610333309100_lmag067-B12","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1111\/hae.70354","article-title":"Platelet hyperreactivity may contribute to thrombotic complications in afibrinogenemia: a case-based observation","volume":"32","author":"Ling","year":"2026","journal-title":"Haemophilia"},{"key":"2026092610333309100_lmag067-B13","doi-asserted-by":"publisher","first-page":"e112935","DOI":"10.1371\/journal.pone.0112935","article-title":"Complex changes in von Willebrand factor-associated parameters are acquired during uncomplicated pregnancy","volume":"9","author":"Drury-Stewart","year":"2014","journal-title":"PLoS One"},{"key":"2026092610333309100_lmag067-B14","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1080\/09537100701206824","article-title":"Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients","volume":"18","author":"Dichiara","year":"2007","journal-title":"Platelets"},{"key":"2026092610333309100_lmag067-B15","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/s0140-6736(71)92107-6","article-title":"Refractory state of platelet aggregation with major operations","volume":"298","author":"O\u2019Brien","year":"1971","journal-title":"Lancet"},{"key":"2026092610333309100_lmag067-B16","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1182\/blood-2004-07-2893","article-title":"P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms","volume":"105","author":"Hardy","year":"2005","journal-title":"Blood"},{"key":"2026092610333309100_lmag067-B17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1136\/jcp.21.6.695","article-title":"Role of erythrocytes in the acute platelet response to operation","volume":"21","author":"Bennett","year":"1968","journal-title":"J Clin Pathol"},{"key":"2026092610333309100_lmag067-B18","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1097\/TA.0000000000004082","article-title":"Injury-induced endotheliopathy: what you need to know","volume":"95","author":"Cardenas","year":"2023","journal-title":"J Trauma Acute Care Surg"},{"key":"2026092610333309100_lmag067-B19","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/ajh.24620","article-title":"Clinical utility of closure times using the platelet function analyzer-100\/200","volume":"92","author":"Favaloro","year":"2017","journal-title":"Am J Hematol"}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/57\/5\/lmag067\/71403057\/lmag067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/57\/5\/lmag067\/71403057\/lmag067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:33:37Z","timestamp":1790433217000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/doi\/10.1093\/labmed\/lmag067\/8836647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmag067","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,4]]},"article-number":"lmag067"}}