{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:27:33Z","timestamp":1793849253609,"version":"4.6.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Insufficient evidence exists for the association between serum dimerized plasmin fragment D (D-dimer), a biomarker for screening thromboembolic diseases, and adverse outcomes in patients with heart failure (HF).<\/jats:p>\n                    <jats:p>We investigated the association between serum D-dimer and the risk of readmission and all-cause mortality in patients with HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 1575 patients hospitalized with HF in China between 2016 and 2019. We explored the smooth curve of the nonlinear relationship between serum D-dimer and adverse outcomes. Logistic regression and saturation threshold analyses were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Smooth curve analysis revealed an inverted U-shaped association between serum D-dimer concentrations and 6-month all-cause mortality. The turning point for serum D-dimer concentration in patients with HF in the highest 6-month mortality risk group was 7.6\u2009mg\/L. Among patients with a D-dimer concentration below 7.6\u2009mg\/L, each 1-mg\/L increase in D-dimer concentration independently contributed to a 20% higher risk for all-cause mortality, independent of other clinical covariates. Regarding readmission risk, smooth curve analysis supported an obvious relationship between serum D-dimer and 6-month readmission risk. Surprisingly, each 1-mg\/L increase in D-dimer concentration was independently associated with a 4% lower risk for readmission within 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Elevated serum D-dimer concentrations have a strong association with increased risk for 6-month mortality, providing evidence for early risk stratification in HF prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag072","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:44:51Z","timestamp":1789213491000},"source":"Crossref","is-referenced-by-count":0,"title":["The relationship between D-dimer and the risk for adverse outcomes in patients with heart failure"],"prefix":"10.1093","volume":"57","author":[{"given":"Xiaoxi","family":"He","sequence":"first","affiliation":[{"name":"Fujian Province, the Mindong Hospital Affiliated to Fujian Medical University , Fuan City,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fujian Province, the Mindong Hospital Affiliated to Fujian Medical University , Fuan City,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruigui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fujian Province, the Mindong Hospital Affiliated to Fujian Medical University , Fuan City,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026110422120553200_lmag072-B1","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1016\/j.jacc.2017.09.024","article-title":"A test in context: D-Dimer","volume":"70","author":"Weitz","year":"2017","journal-title":"J Am Coll 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