{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:27:29Z","timestamp":1793849249543,"version":"4.6.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diffuse large B-cell lymphoma rarely presents primarily with urinary symptoms, making noninvasive diagnosis challenging. We report a case in which urine flow cytometry substantially aided diagnosis and monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 67-year-old man presenting with gross hematuria and painful urination underwent cystoscopy with biopsy and urine flow cytometry. B-cell immunophenotyping was performed using a targeted CD marker panel, and residual disease was tracked longitudinally after chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histopathology suggested aggressive B-cell lymphoma. Urine flow cytometry identified an abnormal mature B-cell population (20.36% of nucleated cells) expressing CD45, CD19, CD20, CD10, FMC7, and \u03bb, confirming a CD5-negative\/CD10-positive phenotype. Following treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, the percentage of abnormal urinary B cells declined to 0.41% at 2 weeks, 0.18% at 1 month, and 0% at 3 months, coinciding with partial clinical remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Urine flow cytometry is a highly accessible, noninvasive, and effective tool. It provides critical diagnostic value and quantitative monitoring utility for hematologic malignancies involving the urinary tract and should complement\u2014not replace\u2014histopathology and urine cytology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag077","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:32:52Z","timestamp":1790508772000},"source":"Crossref","is-referenced-by-count":0,"title":["Flow cytometry in the diagnosis and monitoring of lymphoma based on urine samples: a case report"],"prefix":"10.1093","volume":"57","author":[{"given":"Shuaiyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory, Shenzhen Luohu People\u2019s Hospital , Shenzhen, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory, Shenzhen Luohu 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