{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:40:36Z","timestamp":1792456836814,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sj\u00f6gren disease and celiac disease share autoimmune pathogenesis, and their association is well established. Anti\u2013\u0251-fodrin antibodies (AFAs) are recognized markers of Sj\u00f6gren disease, yet their prevalence in celiac disease has not been assessed. We sought to determine the frequency of AFAs (immunoglobulin A [IgA] and IgG) in adult patients with active celiac disease and compare it with that of a healthy control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 81 adult patients with active celiac disease confirmed by serology and duodenal biopsy were retrospectively included. A total of 90 age-matched and sex-matched healthy blood donors served as controls. The AFAs IgA and IgG were detected by enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We detected AFAs (IgA or IgG) in 33 of 81 (40.74%) of patients with celiac disease vs 7 of 90 (7.78%) control individuals (P\u2009&amp;lt;\u200910\u22126; odds ratio, 8.15). Immunoglobulin A was the predominant isotype (39.51% vs 4.44%, P\u2009&amp;lt;\u200910\u22126; odds ratio, 14.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Anti\u2013\u0251-fodrin antibodies are considerably more prevalent in active celiac disease than in healthy control individuals. Because clinical signs of Sj\u00f6gren disease were absent in our patients, the specificity of AFAs for the disease requires reevaluation. Long-term follow-up of seropositive patients is warranted to determine whether they may develop Sj\u00f6gren disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/labmed\/lmag080","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:02:31Z","timestamp":1792454551000},"source":"Crossref","is-referenced-by-count":0,"title":["Frequency of anti\u2013\u0251-fodrin antibodies in adult patients with active celiac disease"],"prefix":"10.1093","volume":"57","author":[{"given":"Amani","family":"Ifaoui","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Pharmacy, Monastir University , Monastir,","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Frikha","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Pharmacy, Monastir University , Monastir,","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-0750","authenticated-orcid":false,"given":"Sarra","family":"Melayah","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Pharmacy, Monastir University , Monastir,","place":["Tunisia"]},{"name":"Laboratory of Immunology, Farhat Hached Hospital , Sousse,","place":["Tunisia"]},{"name":"LR12SP11, Biochemistry Department, Sahloul University Hospital , Sousse,","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-6513","authenticated-orcid":false,"given":"Mariam","family":"Ghozzi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Pharmacy, Monastir University , Monastir,","place":["Tunisia"]},{"name":"Laboratory of Immunology, Farhat Hached Hospital , Sousse,","place":["Tunisia"]},{"name":"Research Unit \u201cEpidemiology and 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