{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:52:14Z","timestamp":1789847534850,"version":"4.0.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M5c)\u2013like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.<\/jats:p>","DOI":"10.1093\/labmed\/lmw011","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T16:24:42Z","timestamp":1460391882000},"page":"155-157","source":"Crossref","is-referenced-by-count":12,"title":["Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman"],"prefix":"10.1093","volume":"47","author":[{"given":"Bryan","family":"Steussy","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Iowa, Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Lekostaj","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Iowa, Iowa 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