{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:58:41Z","timestamp":1783130321730,"version":"3.54.6"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572069"],"award-info":[{"award-number":["81572069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1093\/labmed\/lmx036","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:22:39Z","timestamp":1504718559000},"page":"238-243","source":"Crossref","is-referenced-by-count":25,"title":["Human Epididymis Protein 4 as a Potential Biomarker of Chronic Kidney Disease in Female Patients With Normal Ovarian Function"],"prefix":"10.1093","volume":"48","author":[{"given":"Tengfei","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"key":"key\n\t\t\t\t20170916020429_CIT0001","first-page":"1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"key\n\t\t\t\t20170916020429_CIT0002","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.ajkd.2014.01.416","article-title":"KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD","volume":"63","year":"2014","journal-title":"Am J Kidney Dis"},{"issue":"9811","key":"key\n\t\t\t\t20170916020429_CIT0003","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0140-6736(11)60178-5","article-title":"Chronic kidney disease","volume":"379","year":"2012","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170916020429_CIT0004","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2010.483","article-title":"The definition, classification and prognosis of chronic kidney disease: a KDIGO Controversies Conference report","volume":"80","year":"2011","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170916020429_CIT0005","first-page":"1","article-title":"Kidney disease: Improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"CKD Work Group","year":"2013","journal-title":"Kidney Int Suppl"},{"issue":"4","key":"key\n\t\t\t\t20170916020429_CIT0006","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/j.1523-1755.2004.00894.x","article-title":"The burden of kidney disease: improving global outcomes","volume":"66","year":"2004","journal-title":"Kidney Int"},{"issue":"4","key":"key\n\t\t\t\t20170916020429_CIT0007","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/ki.2013.553","article-title":"Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar","volume":"86","author":"Chronic Kidney Disease Prognosis Consortium","year":"2014","journal-title":"Kidney Int"},{"issue":"5","key":"key\n\t\t\t\t20170916020429_CIT0008","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1159\/000368915","article-title":"Association between chronic kidney disease progression and cardiovascular disease: results from the CRIC Study","volume":"40","author":"CRIC Study Investigators","year":"2014","journal-title":"Am J Nephrol"},{"issue":"13","key":"key\n\t\t\t\t20170916020429_CIT0009","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","year":"2004","journal-title":"N Engl J Med"},{"issue":"7","key":"key\n\t\t\t\t20170916020429_CIT0010","doi-asserted-by":"crossref","first-page":"e0158765","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease\u2014a systematic review and meta-analysis","volume":"11","year":"2016","journal-title":"PLoS One"},{"issue":"9818","key":"key\n\t\t\t\t20170916020429_CIT0011","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(12)60033-6","article-title":"Prevalence of chronic kidney disease in China: a cross-sectional survey","volume":"379","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"key\n\t\t\t\t20170916020429_CIT0012","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1095\/biolreprod45.2.350","article-title":"A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors","volume":"45","year":"1991","journal-title":"Biol Reprod"},{"issue":"2","key":"key\n\t\t\t\t20170916020429_CIT0013","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1530\/ror.0.0030086","article-title":"Molecular characterization of epididymal proteins","volume":"3","year":"1998","journal-title":"Rev Reprod"},{"issue":"6","key":"key\n\t\t\t\t20170916020429_CIT0014","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/modpathol.3800612","article-title":"Comprehensive analysis of HE4 expression in normal and malignant human tissues","volume":"19","year":"2006","journal-title":"Mod Pathol"},{"issue":"13","key":"key\n\t\t\t\t20170916020429_CIT0015","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","year":"2003","journal-title":"Cancer Res"},{"issue":"3","key":"key\n\t\t\t\t20170916020429_CIT0016","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ygyno.2012.09.003","article-title":"Human epididymis protein 4 (HE4) and ovarian cancer prognosis","volume":"127","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"1","key":"key\n\t\t\t\t20170916020429_CIT0017","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ygyno.2008.08.031","article-title":"A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass","volume":"112","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"10","key":"key\n\t\t\t\t20170916020429_CIT0018","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1681\/ASN.2006040368","article-title":"Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease","volume":"17","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170916020429_CIT0019","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/labmed\/lmv004","article-title":"Serum cystatin C and the risk of coronary heart disease in ethnic Chinese patients with normal renal function","volume":"47","year":"2016","journal-title":"Lab Med"},{"issue":"6","key":"key\n\t\t\t\t20170916020429_CIT0020","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/modpathol.3800612","article-title":"Comprehensive analysis of HE4 expression in normal and malignant human tissues","volume":"19","year":"2006","journal-title":"Mod Pathol"},{"issue":"3","key":"key\n\t\t\t\t20170916020429_CIT0021","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nrneph.2013.2","article-title":"Fibrosis: HE4\u2014a biomarker and target in renal fibrosis","volume":"9","year":"2013","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"key\n\t\t\t\t20170916020429_CIT0022","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm.2989","article-title":"Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis","volume":"19","year":"2013","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170916020429_CIT0023","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1258\/acb.2011.011258","article-title":"Elevated human epididymis protein 4 concentrations in chronic kidney disease","volume":"49","year":"2012","journal-title":"Ann Clin Biochem"}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/48\/3\/238\/19926844\/lmx036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T01:30:56Z","timestamp":1570066256000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/labmed\/article\/48\/3\/238\/4159486\/Human-Epididymis-Protein-4-as-a-Potential"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9,16]]},"published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmx036","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}