{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:19:19Z","timestamp":1778602759812,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,21]]},"DOI":"10.1093\/labmed\/lmx088","type":"journal-article","created":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T04:12:02Z","timestamp":1515211922000},"page":"165-174","source":"Crossref","is-referenced-by-count":7,"title":["Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review"],"prefix":"10.1093","volume":"49","author":[{"given":"Adam M","family":"Szewc","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Diagnostics, Phoenix Children\u2019s Hospital, Phoenix, AZ"},{"name":"Bacterial Special Pathogens Branch (BSPB), Division of High-Consequence Pathogens and Pathology (DHCPP), National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC), Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Phoenix Children\u2019s Hospital, Phoenix, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D","family":"Cage","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Diagnostics, Phoenix Children\u2019s Hospital, Phoenix, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Phoenix Children\u2019s Hospital, Phoenix, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem Pinar","family":"Bulut","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Hepatology, Phoenix Children\u2019s Hospital, Phoenix, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne E","family":"de Mello","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Phoenix Children\u2019s Hospital, Phoenix, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,1,30]]},"reference":[{"issue":"7","key":"key\n\t\t\t\t20180321034416_CIT0001","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s005350200081","article-title":"Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan","volume":"37","author":"Ishikawa","year":"2002","journal-title":"J Gastroenterol"},{"issue":"8","key":"key\n\t\t\t\t20180321034416_CIT0002","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1053\/hupa.2001.26477","article-title":"Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection? A case report and discussion","volume":"32","author":"Aita","year":"2001","journal-title":"Hum Pathol"},{"issue":"9","key":"key\n\t\t\t\t20180321034416_CIT0003","doi-asserted-by":"crossref","first-page":"420","DOI":"10.47102\/annals-acadmedsg.V40N9p420","article-title":"Mismatched bone marrow transplantation for severe aplastic anaemia after liver transplantation for associated acute liver failure","volume":"40","author":"Mali","year":"2011","journal-title":"Ann Acad Med Singapore"},{"key":"key\n\t\t\t\t20180321034416_CIT0004","volume-title":"Focus Diagnostics Package Insert for HHV-6 Primer Pair [package insert]","year":"2011"},{"issue":"4776","key":"key\n\t\t\t\t20180321034416_CIT0005","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.2876520","article-title":"Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders","volume":"234","author":"Salahuddin","year":"1986","journal-title":"Science"},{"key":"key\n\t\t\t\t20180321034416_CIT0006","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jcv.2015.12.002","article-title":"Fulminant hepatic failure attributed to infection with human herpesvirus 6 (HHV-6) in an immunocompetent woman: a case report and review of the literature","volume":"75","author":"Charnot-Katsikas","year":"2016","journal-title":"J Clin Virol"},{"issue":"9","key":"key\n\t\t\t\t20180321034416_CIT0007","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4254\/wjh.v2.i9.345","article-title":"Impact of human herpes virus 6 in liver transplantation","volume":"2","author":"Razonable","year":"2010","journal-title":"World J Hepatol"},{"issue":"8817","key":"key\n\t\t\t\t20180321034416_CIT0008","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0140-6736(92)91801-E","article-title":"Intrauterine transmission of human herpesvirus 6","volume":"340","author":"Aubin","year":"1992","journal-title":"Lancet"},{"issue":"6","key":"key\n\t\t\t\t20180321034416_CIT0009","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/infdis\/169.6.1281","article-title":"Human herpesvirus 6 infection of the female genital tract","volume":"169","author":"Leach","year":"1994","journal-title":"J Infect Dis"},{"issue":"3","key":"key\n\t\t\t\t20180321034416_CIT0010","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/rmv.715","article-title":"Chromosomally integrated human herpesvirus 6: questions and answers","volume":"22","author":"Pellett","year":"2012","journal-title":"Rev Med Virol"},{"issue":"7","key":"key\n\t\t\t\t20180321034416_CIT0011","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/00000478-199707000-00014","article-title":"Herpesvirus 6 variant A infection after heart transplantation with giant cell transformation in bile ductular and gastroduodenal epithelium","volume":"21","author":"Randhawa","year":"1997","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"key\n\t\t\t\t20180321034416_CIT0012","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1086\/525264","article-title":"Human herpesvirus 6 infection of the gastroduodenal mucosa","volume":"46","author":"Halme","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"8693","key":"key\n\t\t\t\t20180321034416_CIT0013","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/0140-6736(90)90983-C","article-title":"Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection","volume":"335","author":"Asano","year":"1990","journal-title":"Lancet"},{"issue":"3","key":"key\n\t\t\t\t20180321034416_CIT0014","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/01.TP.0000069233.13409.DF","article-title":"Human herpesvirus-6 and acute liver failure","volume":"76","author":"H\u00e4rm\u00e4","year":"2003","journal-title":"Transplantation"},{"issue":"5","key":"key\n\t\t\t\t20180321034416_CIT0015","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.transproceed.2013.01.091","article-title":"The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection","volume":"45","author":"H\u00e4rm\u00e4","year":"2013","journal-title":"Transplant Proc"},{"issue":"6","key":"key\n\t\t\t\t20180321034416_CIT0016","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2796.2005.01567.x","article-title":"HHV-6-related acute liver failure in two immunocompetent adults: favourable outcome after liver transplantation and\/or ganciclovir therapy","volume":"258","author":"Cacheux","year":"2005","journal-title":"J Intern Med"},{"issue":"8677","key":"key\n\t\t\t\t20180321034416_CIT0017","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0140-6736(89)92077-1","article-title":"Hepatitis due to human herpesvirus-6","volume":"2","author":"Dubedat","year":"1989","journal-title":"Lancet"},{"issue":"1","key":"key\n\t\t\t\t20180321034416_CIT0018","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1757-1626-1-110","article-title":"Severe hepatitis with autoimmune features following a HHV-6: a case report","volume":"1","author":"Grima","year":"2008","journal-title":"Cases J"},{"issue":"11","key":"key\n\t\t\t\t20180321034416_CIT0019","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/00006454-199511000-00013","article-title":"Fulminant hepatitis in neonates with human herpesvirus 6 infection","volume":"14","author":"Mendel","year":"1995","journal-title":"Pediatr Infect Dis J"},{"issue":"18","key":"key\n\t\t\t\t20180321034416_CIT0020","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1056\/NEJM199105023241818","article-title":"Fulminant hepatitis in primary human herpesvirus-6 infection","volume":"324","author":"Sobue","year":"1991","journal-title":"N Engl J Med"},{"issue":"6","key":"key\n\t\t\t\t20180321034416_CIT0021","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1067\/mpd.2001.119989","article-title":"Acute liver failure in infancy: a 14-year experience of a pediatric liver transplantation center","volume":"139","author":"Durand","year":"2001","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t20180321034416_CIT0022","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2957\/kanzo.41.104","article-title":"A case of HHV-6 mononucleosis occurred as acute hepatitis with special reference to the identification of virus infected cells in liver biopsy specimen using non-isotopic ISH procedure","volume":"41","author":"Imoto","year":"2000","journal-title":"Kanzo"},{"issue":"8693","key":"key\n\t\t\t\t20180321034416_CIT0023","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0140-6736(90)90984-D","article-title":"Human herpesvirus-6 infection with liver injury in neonatal hepatitis","volume":"335","author":"Tajiri","year":"1990","journal-title":"Lancet"},{"issue":"6","key":"key\n\t\t\t\t20180321034416_CIT0024","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/jmv.21143","article-title":"Human herpesvirus-6 infection: a prospective study evaluating HHV-6 DNA levels in liver from children with acute liver failure","volume":"80","author":"Chevret","year":"2008","journal-title":"J Med Virol"},{"issue":"6","key":"key\n\t\t\t\t20180321034416_CIT0025","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1442-200x.2004.01989.x","article-title":"Human herpesvirus 6 fulminant hepatic failure treated by living donor liver transplantation","volume":"46","author":"Ohashi","year":"2004","journal-title":"Pediatr Int"},{"issue":"5","key":"key\n\t\t\t\t20180321034416_CIT0026","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/MPG.0000000000000512","article-title":"Analysis of viral testing in nonacetaminophen pediatric acute liver failure","volume":"59","author":"Schwarz","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"key\n\t\t\t\t20180321034416_CIT0027","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/infdis\/171.2.273","article-title":"Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction","volume":"171","author":"Secchiero","year":"1995","journal-title":"J Infect Dis"},{"issue":"3","key":"key\n\t\t\t\t20180321034416_CIT0028","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/01.tp.0000195771.83614.0b","article-title":"Pretransplant human herpesvirus 6 infection of patients with acute liver failure is a risk factor for posttransplant human herpesvirus 6 infection of the liver","volume":"81","author":"H\u00e4rm\u00e4","year":"2006","journal-title":"Transplantation"},{"issue":"4 Pt 1","key":"key\n\t\t\t\t20180321034416_CIT0029","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1542\/peds.102.4.900","article-title":"Prospective study of persistence and excretion of human herpesvirus-6 in patients with exanthem subitum and their parents","volume":"102","author":"Suga","year":"1998","journal-title":"Pediatrics"},{"issue":"5","key":"key\n\t\t\t\t20180321034416_CIT0030","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2011.12.017","article-title":"High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis","volume":"56","author":"Pischke","year":"2012","journal-title":"J Hepatol"}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/49\/2\/165\/24433346\/lmx088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T09:31:01Z","timestamp":1719739861000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/49\/2\/165\/4830224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,30]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,1,30]]},"published-print":{"date-parts":[[2018,3,21]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmx088","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5]]},"published":{"date-parts":[[2018,1,30]]}}}