{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:09:00Z","timestamp":1785863340770,"version":"3.56.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the advantages of using anti-M\u00fcllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We compared data from 56 Han Chinese patients with PCOS and 52 female control Han Chinese individuals in terms of biochemical markers and the antral follicle count (AFC). Then, the correlation between serum AMH levels and various endocrine and metabolic factors was analyzed. We generated receiver operating characteristic (ROC) curves to assess the usefulness of AMH, AFC, the luteinizing hormone\/follicle-stimulating hormone (LH\/FSH) ratio, and testosterone (T), to discriminate between the PCOS and control groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The LH\/FSH ratio, homeostatis model assessment of insulin resistance (HOMA-IR), testosterone (T), blood glucose (Glu), triglyceride (TG), body mass index (BMI), AFC and, in particular, serum AMH level were significantly higher in the PCOS group than in the control group (P &lt;.05; P &lt;.001). The serum AMH level had a significant positive effect on the likelihood of AFC changes in patients with PCOS and control-group women. The areas under the ROC curve (AUC) of AMH, AFC, LH\/FSH ratio, and T were 0.952, 0.778, 0.760, and 0.665, respectively. The best cutoff point for AMH was 6.09 ng per mL, with sensitivity of 88% and specificity of 88%.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmy068","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T07:25:06Z","timestamp":1540538706000},"page":"236-242","source":"Crossref","is-referenced-by-count":7,"title":["Advantages of Serum Anti-M\u00fcllerian Hormone as a Marker for Polycystic Ovarian Syndrome"],"prefix":"10.1093","volume":"50","author":[{"given":"Xinyan","family":"Shi","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"},{"name":"Clinical Laboratory, Hangzhou Women\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Peng","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"},{"name":"Clinical Laboratory, Lishui People\u2019s Hospital, Lishui, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Hangzhou Women\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Miao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Hangzhou Women\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ye","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Hangzhou Women\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"issue":"6","key":"2019071612060750800_CIT0001","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019071612060750800_CIT0002","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.mcna.2014.09.003","article-title":"Polycystic ovarian syndrome","volume":"99","author":"Trikudanathan","year":"2015","journal-title":"Med Clin N Am"},{"issue":"1","key":"2019071612060750800_CIT0003","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Working Group","year":"2004","journal-title":"Hum Reprod"},{"issue":"5","key":"2019071612060750800_CIT0004","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0092-8674(86)90783-X","article-title":"Isolation of the bovine and human genes for M\u00fcllerian inhibiting substance and expression of the human gene in animal cells","volume":"45","author":"Cate","year":"1986","journal-title":"Cell"},{"issue":"10","key":"2019071612060750800_CIT0005","first-page":"3836","article-title":"Expression of anti-M\u00fcllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells","volume":"84","author":"Rajpert-De Meyts","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"1\u20132","key":"2019071612060750800_CIT0006","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mce.2004.09.008","article-title":"Anti-M\u00fcllerian hormone and folliculogenesis","volume":"234","author":"Visser","year":"2005","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"2019071612060750800_CIT0007","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.fertnstert.2013.04.019","article-title":"Antim\u00fcllerian hormone inhibits follicle-stimulating hormone-induced adenylyl cyclase activation, aromatase expression, and estradiol production in human granulosa-lutein cells","volume":"100","author":"Chang","year":"2013","journal-title":"Fertil Steril"},{"issue":"6","key":"2019071612060750800_CIT0008","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4103\/2230-8210.167548","article-title":"Can anti-Mullerian hormone replace ultrasonographic evaluation in polycystic ovary syndrome? 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