{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:33Z","timestamp":1789609233875,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The main clinical distinction between post-transfusion purpura (PTP) and idiopathic thrombocytopenic purpura (ITP) is the sudden development of severe thrombocytopenia in the days after transfusion. Herein, we report the case of a 53-year-old Caucasian woman who developed multiple myeloma (MM) after peripheral blood-stem-cell transplant (PBSCT), along with severe thrombocytopenia (with a nadir of 1 \u00d7 109\/L); she also experienced severe adverse events after each platelet transfusion, including the first one. These reactions were absent with any other transfused blood products. The results of an human leukocyte antigen (HLA) class-1 panel reactive antibody assay were 0%, and the results of a platelet-antibody screening assay were positive for HLA class-1 antibodies and glycoprotein (Gp)IIb\/IIIa antibodies. Her platelet count reached 42 \u00d7 109 per L on day 50, after rituximab on day 22 and daratumumab on day 29. Her clinical scenario was most consistent with the course of PTP.<\/jats:p>","DOI":"10.1093\/labmed\/lmz004","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T15:23:41Z","timestamp":1549380221000},"page":"396-400","source":"Crossref","is-referenced-by-count":4,"title":["Post-Transfusion Purpura Mimicking Idiopathic Thrombocytopenic Purpura: A Case Report"],"prefix":"10.1093","volume":"50","author":[{"given":"Chelsea","family":"Milito","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Masel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Henrichs","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-3173","authenticated-orcid":false,"given":"Amy E","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Kirkley","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Aljitawi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Transfusion Medicine Unit, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed A","family":"Refaai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"issue":"4","key":"2019101009585915400_CIT0001","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood.V45.4.529.bloodjournal454529","article-title":"Post-transfusion purpura: a heterogeneous syndrome","volume":"45","author":"Zeigler","year":"1975","journal-title":"Blood."},{"issue":"1","key":"2019101009585915400_CIT0002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1160\/TH07-08-0513","article-title":"Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management","volume":"99","author":"Stasi","year":"2008","journal-title":"Thromb Haemost."},{"issue":"1","key":"2019101009585915400_CIT0003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-3148.2001.00280.x","article-title":"Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions","volume":"11","author":"Vo","year":"2001","journal-title":"Transfus Med."},{"issue":"6","key":"2019101009585915400_CIT0004","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.transci.2018.09.001","article-title":"Released washed platelet concentrates are effective and safe in patients with a history of transfusion reactions","volume":"57","author":"Fujiwara","year":"2018","journal-title":"Transfus Apher Sci."},{"issue":"1","key":"2019101009585915400_CIT0005","first-page":"6","article-title":"A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia [ISRCTN76536440]","volume":"4","author":"Blumberg","year":"2004","journal-title":"BMC Blood Disord."},{"issue":"5","key":"2019101009585915400_CIT0006","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1537-2995.2010.02897.x","article-title":"A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal","volume":"51","author":"Veeraputhiran","year":"2011","journal-title":"Transfusion."},{"issue":"3","key":"2019101009585915400_CIT0007","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ajh.2830090312","article-title":"Post-transfusion purpura: an enigma of alloimmunization","volume":"9","author":"Lau","year":"1980","journal-title":"Am J Hematol."},{"key":"2019101009585915400_CIT0008","doi-asserted-by":"crossref","first-page":"pii: bcr2013008860","DOI":"10.1136\/bcr-2013-008860","article-title":"Post-transfusion purpura: a rare and life-threatening aetiology of thrombocytopenia","volume":"2013","author":"Padhi","year":"2013","journal-title":"BMJ Case Rep."},{"key":"2019101009585915400_CIT0009","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1182\/blood.V122.21.4834.4834","article-title":"Diagnosis and management of POST-transfusion purpura - case report","volume":"122","author":"Conti","year":"2013","journal-title":"Blood."},{"key":"2019101009585915400_CIT0010","volume-title":"Transfusion Reactions","author":"Popovsky","year":"2012","edition":"4th ed"},{"issue":"2","key":"2019101009585915400_CIT0011","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1182\/blood.V68.2.347.347","article-title":"Studies on the pathophysiology of posttransfusion purpura","volume":"68","author":"Kickler","year":"1986","journal-title":"Blood."},{"issue":"3","key":"2019101009585915400_CIT0012","first-page":"380","article-title":"Advances in alloimmune thrombocytopenia: perspectives on current concepts of human platelet antigens, antibody detection strategies, and genotyping","volume":"13","author":"Hayashi","year":"2015","journal-title":"Blood Transfus."},{"issue":"19","key":"2019101009585915400_CIT0013","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1056\/NEJMoa1807438","article-title":"Daratumumab for delayed red-cell engraftment after allogeneic transplantation","volume":"379","author":"Chapuy","year":"2018","journal-title":"N Engl J Med."}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/50\/4\/396\/30128519\/lmz004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/50\/4\/396\/30128519\/lmz004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T23:36:45Z","timestamp":1573861005000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/50\/4\/396\/5420471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,3,27]]},"published-print":{"date-parts":[[2019,10,10]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmz004","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,3,27]]}}}