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One type of \u03b1-SPD is gray platelet syndrome (GPS), caused by mutations in the neurobeachin-like 2 (NBEAL2) gene that results in a bleeding diathesis, thrombocytopenia, splenomegaly, and progressive myelofibrosis. Due to the lack of \u03b1-granules, platelets have a gray and degranulated appearance by light microscopy. However, definitive diagnosis of GPS requires confirmation of \u03b1-granule deficiency by electron microscopy. Treatment is nonspecific, with the conservative utilization of platelet transfusions being the most important form of therapy. We present a case of a 17-year-old female with a past medical history of thrombocytopenia, first identified at the age of five. Her clinical symptomatology included chronic fatigue, gingival bleeding, bruising, menorrhagia, and leg pain. This report will discuss both the clinical and the pathophysiologic aspects of this rare platelet disorder.<\/jats:p>","DOI":"10.1093\/labmed\/lmz013","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T21:18:50Z","timestamp":1561065530000},"page":"406-420","source":"Crossref","is-referenced-by-count":3,"title":["A Case of Chronic Thrombocytopenia in a 17-Year-Old Female"],"prefix":"10.1093","volume":"50","author":[{"given":"Roger","family":"Riley","sequence":"first","affiliation":[{"name":"Departments of Pathology, Virginia Commonwealth University (VCU) School of Medicine, Richmond"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Khan","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Virginia Commonwealth University (VCU) School of Medicine, Richmond"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shella","family":"Pai","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Virginia Commonwealth University (VCU) School of Medicine, Richmond"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Warmke","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Winkler","sequence":"additional","affiliation":[{"name":"Associated Pathologists, Nashville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Gunning","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Toledo College of Medicine, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"issue":"4","key":"2019101009590476800_CIT0001","first-page":"678","article-title":"Immune functions of platelets","volume":"112","author":"Duerschmied","year":"2014","journal-title":"Thromb Haemost."},{"issue":"2","key":"2019101009590476800_CIT0002","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tmrv.2014.11.006","article-title":"Platelets are not just for clots","volume":"29","author":"McFadyen","year":"2015","journal-title":"Transfus Med Rev."},{"key":"2019101009590476800_CIT0003","first-page":"9","article-title":"Platelet ultrastructure","volume-title":"Thromb Diath Haemorrh Suppl.","author":"Rodman","year":"1967"},{"key":"2019101009590476800_CIT0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-29423-5_1","article-title":"Platelets: production, morphology and ultrastructure","volume-title":"Antiplatelet Agents.Handbook of Experimental Pharmacology","author":"Thon","year":"2012"},{"issue":"3","key":"2019101009590476800_CIT0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0035-1564835","article-title":"Platelet physiology","volume":"42","author":"Gremmel","year":"2016","journal-title":"Semin Thromb Hemost."},{"issue":"1","key":"2019101009590476800_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0049-3848(99)00015-8","article-title":"Platelet dense granules: structure, function and implications for haemostasis","volume":"95","author":"McNicol","year":"1999","journal-title":"Thromb Res."},{"key":"2019101009590476800_CIT0007","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1017\/S1431927603446813","article-title":"The platelet delta-granule and its role in hemostasis","volume":"9","author":"Gunning","year":"2003","journal-title":"Microsc Microanal."},{"key":"2019101009590476800_CIT0008","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genom.9.081307.164303","article-title":"Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics","volume":"9","author":"Huizing","year":"2008","journal-title":"Annu Rev Genomics Hum Genet."},{"issue":"4124","key":"2019101009590476800_CIT0009","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1126\/science.183.4124.537","article-title":"Serotonin storage in platelets: estimation of storage-packet size","volume":"183","author":"Costa","year":"1974","journal-title":"Science."},{"issue":"5","key":"2019101009590476800_CIT0010","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0049-3848(78)90277-3","article-title":"Quantitative evaluation of mepacrine labelled human platelet dense bodies in normals and in cases of peripheral thrombocytopenia","volume":"12","author":"Boneu","year":"1978","journal-title":"Thromb Res."},{"issue":"1","key":"2019101009590476800_CIT0011","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1182\/blood.V64.1.185.bloodjournal641185","article-title":"Heterogeneity of human whole blood platelet subpopulations. 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