{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:10:28Z","timestamp":1773288628743,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16-15-10340"],"award-info":[{"award-number":["16-15-10340"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Case-control study including 50 patients with CKD and 20 healthy volunteers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>SAM level and SAM\/SAH ratio in urine were significantly lower in patients than in control individuals (P &amp;lt;.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM\/SAH ratio in urine (P = .01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM\/SAH ratio in urine. Thus, use of the urinary SAM\/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmz035","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T15:37:41Z","timestamp":1554824261000},"page":"80-85","source":"Crossref","is-referenced-by-count":12,"title":["Low S-adenosylmethionine\/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease"],"prefix":"10.1093","volume":"51","author":[{"given":"Maria Petrovna","family":"Kruglova","sequence":"first","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergej Vital\u2019evich","family":"Grachev","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University) of the 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