{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:42Z","timestamp":1753877262286,"version":"3.41.2"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Heart Institute, Cairo, Egypt"},{"name":"National Research Center, Cairo, Egypt"},{"name":"Al-Azhar University, Cairo, Egypt"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Information on the relationship between circulating cholesteryl ester transfer protein (CETP) levels and coronary heart disease (CHD) incidence (and also, therefore, acute coronary syndrome [ACS]) is conflicting. Many studies have been published concerning this relationship, most of which have incompatible results. In our study, we aimed to determine serum CETP levels in subject individuals with ACS and healthy control individuals, and the association of those levels with Taq IB polymorphism. The current study was conducted with 62 hospitalized patients who had been diagnosed with ACS and 26 controls. All subjects were selected from a previous study of which we are among the coauthors. Serum CETP levels were determined by quantitative enzyme-linked immunosorbent assay (ELISA). The mean serum CETP levels in all patients were significantly higher than those in controls. CETP TaqIB polymorphism affected serum CETP levels, with higher serum CETP for the GA genotype in both groups than in other genotypes. Although the AA genotype showed higher CETP levels than the GG genotype in patients with ACS, the GG showed higher CETP than the AA in healthy controls. Our results support an association between high serum CETP and ACS incidence. Our study helped address some of the controversies regarding the relationship of serum CETP mass to atherosclerosis, in addition to the association of ACS occurrence with circulating CETP levels.<\/jats:p>","DOI":"10.1093\/labmed\/lmz043","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T19:09:46Z","timestamp":1557601786000},"source":"Crossref","is-referenced-by-count":2,"title":["Association of Serum Cholesterol Ester Transfer Protein Levels with Taq IB Polymorphism in Acute Coronary Syndrome"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6983-1900","authenticated-orcid":false,"given":"Noha N","family":"Amer","sequence":"first","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy (Girls), Al Azhar University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal M","family":"Shaaban","sequence":"additional","affiliation":[{"name":"National Heart Institute, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"issue":"2","key":"2019091013151129800_CIT0001","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/labmed\/lmw071","article-title":"Association of cholesterol ester transfer protein Taq IB polymorphism with acute coronary syndrome in Egyptian national patients","volume":"48","author":"Abdel Maksoud","year":"2017","journal-title":"Lab Med."},{"key":"2019091013151129800_CIT0002","doi-asserted-by":"crossref","first-page":"818","DOI":"10.12659\/MSM.889550","article-title":"Cholesterol ester transfer protein (CETP) gene polymorphism and selected parameters of lipid metabolism in children from families with history of cardiovascular system diseases","volume":"19","author":"Pac-Ko\u017cuchowska","year":"2013","journal-title":"Med Sci Monit."},{"issue":"1","key":"2019091013151129800_CIT0003","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.atherosclerosis.2013.01.046","article-title":"Plasma lipid transfer proteins and cardiovascular disease. 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