{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:43Z","timestamp":1753877263024,"version":"3.41.2"},"reference-count":147,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular diseases (CVDs) are a major cause of mortality worldwide. The results of various studies have shown that abnormality in the frequency and function of blood cells can be involved in CVD complications. In this review, we have focused on abnormalities in the expression of the CD (cluster of differentiation) markers of blood cells to assess the association of these abnormalities with CVD prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified the relevant literature through a PubMed search (1990\u20132018) of English-language articles using the terms \u201cCardiovascular diseases\u201d, \u201cCD markers\u201d, \u201cleukocytes\u201d, \u201cplatelets\u201d, and \u201cendothelial cells\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There is a variety of mechanisms for the effect of CD-marker expressions on CVDs prognosis, ranging from proinflammatory processes to dysfunctional effects in blood cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Considering the possible effects of CD-marker expression on CVDs prognosis, particularly prognosis of acute myocardial infarction and atherosclerosis, long-term studies in large cohorts are required to identify the prognostic value of CD markers and to target them with appropriate therapeutic agents.<\/jats:p><\/jats:sec>","DOI":"10.1093\/labmed\/lmz049","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T19:12:53Z","timestamp":1560453173000},"source":"Crossref","is-referenced-by-count":1,"title":["Expression of Blood Cells Associated CD Markers and Cardiovascular Diseases: Clinical Applications in Prognosis"],"prefix":"10.1093","author":[{"given":"Habib","family":"Haybar","sequence":"first","affiliation":[{"name":"Atherosclerosis Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masumeh","family":"Maleki Behzad","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Shahrabi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narges","family":"Ansari","sequence":"additional","affiliation":[{"name":"Isfahan Bone Metabolic Disorders Research Center, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8494-5594","authenticated-orcid":false,"given":"Najmaldin","family":"Saki","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"issue":"16","key":"2019072413182713900_CIT0001","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2010.11.041","article-title":"Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence","volume":"57","author":"Folsom","year":"2011","journal-title":"J Am Coll Cardiol."},{"issue":"5","key":"2019072413182713900_CIT0002","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pcad.2014.12.004","article-title":"The vasculature in cardiovascular diseases: will the vasculature tell us what the future holds?","volume":"57","author":"Phillips","year":"2015","journal-title":"Prog Cardiovasc 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