{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:11:41Z","timestamp":1726434701190},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myelodysplastic syndrome (MDS) that evolves into acute leukemia with blasts of mixed phenotypes has rarely been reported and has no distinct diagnostic category. Herein, we describe a 79-year-old Korean female patient with MDS\u2013excess blasts (MDS-EB) that evolved into acute leukemia; the blasts simultaneously expressed B-lymphoid and myeloid antigens. The patient was diagnosed with MDS-EB with blasts of myeloid lineage coexpressing a few B-lymphoid antigens with 7q and 20q abnormalities. The disease progressed to acute leukemia with blasts carrying more B-lymphoid antigens, which was immunophenotypically compatible with B-lymphoid\/myeloid acute leukemia. Unlike previously reported patients whose blast populations are bilineal, our patient is the first with biphenotypic acute leukemia that progressed from MDS. The diagnosis of our patient introduces the possibility that many other types of biphenotypic acute leukemia may have gone undiagnosed and encourages hematologists to designate a specific diagnostic category for this type of disease, so that it can more readily be detected and studied in the future.<\/jats:p>","DOI":"10.1093\/labmed\/lmz054","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T13:05:51Z","timestamp":1561467951000},"page":"288-295","source":"Crossref","is-referenced-by-count":1,"title":["Mixed Phenotype Acute Leukemia that Evolved from Myelodysplastic Syndrome with Excess Blasts"],"prefix":"10.1093","volume":"51","author":[{"given":"Miyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Young","family":"Zang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Young","family":"Park","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousun","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Kyung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"issue":"1","key":"2020050607574526900_CIT0001","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jmoldx.2016.10.002","article-title":"Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists","volume":"19","author":"Li","year":"2017","journal-title":"J Mol Diagn."},{"key":"2020050607574526900_CIT0002","first-page":"97","article-title":"Myelodysplastic syndromes","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Arber","year":"2017","edition":"4"},{"key":"2020050607574526900_CIT0003","first-page":"129","article-title":"Acute myeloid leukemia and related precursors neopalsms. Acute myeloid leukaemia with myelodysplasia-related changes","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Arber","year":"2017","edition":"4"},{"key":"2020050607574526900_CIT0004","first-page":"181","article-title":"Acute leukaemias of ambiguous lineage","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Borowitz","year":"2017","edition":"4"},{"key":"2020050607574526900_CIT0005","first-page":"150","article-title":"Acute leukemias of ambiguous lineage","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Borowitz","year":"2008","edition":"4"},{"issue":"11","key":"2020050607574526900_CIT0006","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1182\/blood-2010-10-314682","article-title":"Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification","volume":"117","author":"Matutes","year":"2011","journal-title":"Blood."},{"issue":"4","key":"2020050607574526900_CIT0007","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000322594","article-title":"Clinical characteristics, biological profile, and outcome of biphenotypic acute leukemia: a case series","volume":"125","author":"Zhang","year":"2011","journal-title":"Acta Haematol."},{"issue":"12","key":"2020050607574526900_CIT0008","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.3324\/haematol.2009.014829","article-title":"What is the optimal treatment for biphenotypic acute leukemia?","volume":"94","author":"Zheng","year":"2009","journal-title":"Haematologica."},{"issue":"11","key":"2020050607574526900_CIT0009","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3324\/haematol.2012.064485","article-title":"Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification","volume":"97","author":"Yan","year":"2012","journal-title":"Haematologica."},{"issue":"1","key":"2020050607574526900_CIT0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/bjh.12484","article-title":"Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview","volume":"163","author":"Manola","year":"2013","journal-title":"Br J Haematol."},{"issue":"11","key":"2020050607574526900_CIT0011","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1080\/10428194.2018.1443451","article-title":"AML with MDS-related changes and blasts of mixed lineage: time for a new provisional entity?","volume":"59","author":"Klairmont","year":"2018","journal-title":"Leuk Lymphoma."},{"issue":"12","key":"2020050607574526900_CIT0012","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1182\/blood-2016-06-723098","article-title":"Acute myeloid leukemia with myelodysplasia-related changes demonstrating mixed-lineage phenotype","volume":"128","author":"Kajal","year":"2016","journal-title":"Blood."},{"issue":"16","key":"2020050607574526900_CIT0013","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1182\/blood-2014-10-551465","article-title":"How I treat mixed-phenotype acute leukemia","volume":"125","author":"Wolach","year":"2015","journal-title":"Blood."}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/51\/3\/288\/33174969\/lmz054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/51\/3\/288\/33174969\/lmz054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T14:59:39Z","timestamp":1588777179000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/51\/3\/288\/5556794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,8,30]]},"published-print":{"date-parts":[[2020,5,6]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmz054","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"type":"print","value":"0007-5027"},{"type":"electronic","value":"1943-7730"}],"subject":[],"published-other":{"date-parts":[[2020,5]]},"published":{"date-parts":[[2019,8,30]]}}}