{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:18:46Z","timestamp":1740136726026,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Scientific Research Project Coordination Unit of Istanbul University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine CLLU1 gene levels and the relationship of that gene among other prognostic parameters in patients with chronic lymphocytic leukemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Bone-marrow infiltration pattern, \u03b22-microglobulin (\u03b2\u200a2-M), cluster of differentiation (CD)38, and ZAP-70 status were recorded. CLLU1 levels were assessed by real-time polymerase chain reaction (RT-PCR) and expressed as folds. The relationship between CLLU1 and other known prognostic parameters was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CLLU1 expression was positive in 81 patients and negative in 3 patients. The median (interquartile range [IQR]) CLLU1 level was 6.45 folds (3.75\u201316.57 folds) in patients with \u03b2\u200a2-M normal values and 16.22 folds (3.91\u201362.00 folds) in patients with increased \u03b2\u200a2-M (P = .15). Patients with a higher CD38 value than the median level had 3 times higher CLLU1 levels than the other group (P = .07). The median (IQR) CLLU1 level was 4.25 folds (2.75\u201313.71 folds) in patients with CLL who tested negative on ZAP-70, whereas it was 49.52 folds (15.06\u2013446.36 folds) in those who tested positive via ZAP-70 (P = .005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CLLU1 is a specific parameter to CLL, and its level corresponds well with the ZAP-70 level.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmz058","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:21:46Z","timestamp":1563967306000},"page":"259-264","source":"Crossref","is-referenced-by-count":1,"title":["The Impact and Prognostic Significance of Chronic Lymphocytic Leukemia Upregulated 1 (CLLU1) Gene Expression in Patients with Chronic Lymphocytic Leukemia: A Single Center Experience"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-4884","authenticated-orcid":false,"given":"Mustafa","family":"Sevinc","sequence":"first","affiliation":[{"name":"Department of Nephrology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayd\u0131n","family":"Karabulut","sequence":"first","affiliation":[{"name":"Vocational School of Health Services, Health Sciences University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9568-0894","authenticated-orcid":false,"given":"Ahmet Emre","family":"Eskazan","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University\u2014Cerrahpasa, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzin","family":"Catal Tatonyan","sequence":"first","affiliation":[{"name":"Genera Diagnostic Laboratories, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Ozbek","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Medical Faculty, Acibadem University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teoman","family":"Soysal","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University\u2014Cerrahpasa, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"issue":"1","key":"2020050607574895200_CIT0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beha.2010.01.001","article-title":"Diagnostic issues in chronic lymphocytic leukaemia 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