{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:32:43Z","timestamp":1779388363316,"version":"3.53.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Anti-M is most often assumed to be naturally occurring and can be comprised of a mixture of predominantly immunoglobulin(Ig)M with a lesser IgG component. Anti-M-antibodies usually do not react at 37\u00b0C and therefore are considered to be of little clinical significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A 28-year-old man presented with hemorrhagic shock from numerous injuries sustained in a motor vehicle collision. The patient received several units of red blood cells (RBCs). The antibody screen, the direct antiglobulin test (DAT), and the RBC genotype were sent for laboratory evaluation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 12 days after the first antibody screening result was negative (7 days after transfusion), the lowest hemoglobin value was 5.5 g per dL, and we observed a positive antibody screening result and DAT with immunoglobulin (Ig)G anti-M identified. After transfusion of 4 units of M antigen\u2013negative RBC, the post-transfusion hemoglobin level increased to 8.9 g per dL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Obtaining M antigen\u2013negative compatible RBCs is necessary in patients demonstrating IgG anti-M in plasma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmz078","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T19:28:08Z","timestamp":1569266888000},"page":"426-429","source":"Crossref","is-referenced-by-count":5,"title":["Anti-M\u2013Induced Delayed Hemolytic Transfusion Reaction"],"prefix":"10.1093","volume":"51","author":[{"given":"Emmanuel A","family":"Fadeyi","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Wake Forest University School of Medicine"},{"name":"Department of Pathology & Laboratory Medicine, Wake Forest Baptist Health, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfeq","family":"Naal","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Wake Forest University School of Medicine"},{"name":"Department of Pathology & Laboratory Medicine, Wake Forest Baptist Health, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Green","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Wake Forest University School of Medicine"},{"name":"Department of Pathology & Laboratory Medicine, Wake Forest Baptist Health, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie H","family":"Simmons","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Wake Forest Baptist Health, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Rose","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Wake Forest Baptist Health, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J","family":"Pomper","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Wake Forest University School of Medicine"},{"name":"Department of Pathology & Laboratory Medicine, Wake Forest Baptist Health, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"issue":"1","key":"2020070804441838900_CIT0001","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tmrv.2006.08.003","article-title":"Blood group antibodies and their significance in transfusion medicine","volume":"21","author":"Poole","year":"2007","journal-title":"Transfus Med Rev."},{"issue":"1","key":"2020070804441838900_CIT0002","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/vox.12717","article-title":"International Society of Blood Transfusion working party on red cell immunogenetics and blood group terminology: report of the Dubai, Copenhagen and Toronto meetings","volume":"114","author":"Storry","year":"2019","journal-title":"Vox Sang."},{"key":"2020070804441838900_CIT0003","first-page":"233","volume-title":"Technical Manual","author":"Fung","year":"2017","edition":"19"},{"key":"2020070804441838900_CIT0004","doi-asserted-by":"crossref","DOI":"10.1002\/9780470986868","volume-title":"Blood Transfusion in Clinical Medicine","author":"Klein","year":"2005","edition":"11"},{"issue":"8","key":"2020070804441838900_CIT0005","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1046\/j.1537-2995.1990.30891020325.x","article-title":"The differentiation of delayed serologic and delayed hemolytic transfusion reactions: incidence, long-term serologic findings, and clinical significance","volume":"30","author":"Ness","year":"1990","journal-title":"Transfusion."},{"issue":"1","key":"2020070804441838900_CIT0006","first-page":"99","article-title":"Spectrum of anti-M: a report of three unusual cases","volume":"12","author":"Das","year":"2014","journal-title":"Blood Transfus."},{"issue":"2","key":"2020070804441838900_CIT0007","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0973-6247.42695","article-title":"Anti-M: report of two cases and review of literature","volume":"2","author":"Tondon","year":"2008","journal-title":"Asian J Transfus Sci."},{"issue":"4","key":"2020070804441838900_CIT0008","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1046\/j.1537-2995.1983.23483276867.x","article-title":"Anti-M causing delayed hemolytic transfusion reaction","volume":"23","author":"Alperin","year":"1983","journal-title":"Transfusion."},{"issue":"1","key":"2020070804441838900_CIT0009","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/trf.15054","article-title":"Hemolytic disease of the fetus and newborn due to alloanti-M: three Chinese case reports and a review of the literature","volume":"59","author":"Li","year":"2019","journal-title":"Transfusion"},{"issue":"6","key":"2020070804441838900_CIT0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1046\/j.1365-2257.1999.00260.x","article-title":"Delayed haemolytic transfusion reaction caused by anti-M antibody in a patient receiving interleukin-2 and interferon for metastatic renal cell cancer","volume":"21","author":"Parry-Jones","year":"1999","journal-title":"Clin Lab Haematol."},{"issue":"1","key":"2020070804441838900_CIT0011","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1046\/j.1365-2141.1998.00970.x","article-title":"Delayed haemolytic transfusion reaction due to anti-M antibody","volume":"103","author":"Sancho","year":"1998","journal-title":"Br J Haematol."}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/51\/4\/426\/33473410\/lmz078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/labmed\/article-pdf\/51\/4\/426\/33473410\/lmz078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T08:44:35Z","timestamp":1594197875000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/51\/4\/426\/5637934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,22]]},"published-print":{"date-parts":[[2020,7,8]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmz078","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2019,11,22]]}}}