{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:44:34Z","timestamp":1791567874961,"version":"4.3.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Royal Golden Jubilee PhD program of the Thailand Research Fund","award":["PHD\/0080\/2556"],"award-info":[{"award-number":["PHD\/0080\/2556"]}]},{"name":"National Research University Program of Khon Kaen University","award":["NRU592016"],"award-info":[{"award-number":["NRU592016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To establish a new indicator derived from reticulocyte hemoglobin (Ret-He) content and red blood cell (RBC) indices for screening for iron deficiency anemia (IDA) in an area in whch thalassemia is prevalent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Blood specimens from 304 women aged between 18 and 30 years residing in northeast Thailand were collected and measured for RBC and reticulocyte parameters. Iron deficiency was diagnosed when a participant had a serum ferritin level of less than 15 ng per mL. Thalassemia genotypes were defined by hemoglobin (Hb) and DNA analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the total participants, 25% had iron deficiency (ID) and 50% carried the thalassemia gene. Various mathematical formulas were established and analyzed using the receiver operating characteristic (ROC) curve. The formula derived from Ret-He: (Ret-He\/RDW-SD) \u00d7 10, was the best predictor for identifying ID among participants (area under the curve [AUC]\u2005=\u20050.812). Further testing of this indicator among individuals with positive thalassemia-screening results revealed stronger performance with an AUC of 0.874.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The findings indicate that the formula derived from Ret-He might be applicable for screening ID in areas in which thalassemia is prevalent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmz099","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T12:10:28Z","timestamp":1575547828000},"page":"498-506","source":"Crossref","is-referenced-by-count":6,"title":["A New Indicator Derived From Reticulocyte Hemoglobin Content for Screening Iron Deficiency in an Area Prevalent for Thalassemia"],"prefix":"10.1093","volume":"51","author":[{"given":"Jutatip","family":"Jamnok","sequence":"first","affiliation":[{"name":"Graduate School, Medical Science Program, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanokwan","family":"Sanchaisuriya","sequence":"additional","affiliation":[{"name":"Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaninthorn","family":"Chaitriphop","sequence":"additional","affiliation":[{"name":"Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattara","family":"Sanchaisuriya","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Khon Kaen University, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goonnapa","family":"Fucharoen","sequence":"additional","affiliation":[{"name":"Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supan","family":"Fucharoen","sequence":"additional","affiliation":[{"name":"Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"2020090103122511000_CIT0001","volume-title":"Iron deficiency anaemia: assessment, prevention, and control. 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