{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:00:08Z","timestamp":1771466408259,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100018811","name":"Universidad de La Rioja","doi-asserted-by":"publisher","award":["SAF2016-76571-R"],"award-info":[{"award-number":["SAF2016-76571-R"]}],"id":[{"id":"10.13039\/501100018811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad of Spain","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The emergence and spread of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals is a major global public health concern. The current study sought to characterize 25 MRSA clinical isolates collected in a Tunisian hospital from December 2015 to September 2016, with the genetic lineages, virulence factors, and antibiotic resistance mechanisms determined for these isolates. Three spa-types were detected: t037 (23 isolates), t932, and t2235 (one isolate each). Isolates were ascribed to agr I (n\u00a0=\u00a020), agr II (n\u00a0=\u00a01), with four nontypeable isolates. Depending on sequence type (ST), the 25 MRSA isolates were assigned to two clonal complexes (CC8 and CC5), with a predominance of the lineage ST239-CC8 (n\u00a0=\u00a024; 96%). All isolates belonging to CC8 had the SCCmec type III, while the unique CC5 isolate had SCCmec type IV. Antimicrobial susceptibility testing revealed high levels of resistance to aminoglycosides, tetracycline, ciprofloxacin and rifampicin for the majority of isolates belonging to the ST239-CC8 lineage. The ST149-CC5 isolate was susceptible to non-\u03b2-lactam antibiotics. One isolate harbored the tsst-1 gene (4%); however, lukS\/LukF-PV, eta and etb genes were not detected. The MDR ST239-CC8 clone would seem to be widespread in this hospital. Therefore, a rigorous hygienic control system is urgently required.<\/jats:p>","DOI":"10.1093\/lambio\/ovac001","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T13:41:36Z","timestamp":1712583696000},"source":"Crossref","is-referenced-by-count":1,"title":["Widespread of the Vienna\/Hungarian\/Brazilian CC8-ST239-SCC<i>mec<\/i> III MRSA clone in patients hospitalized in the Tunisian Burn and Traumatology Center"],"prefix":"10.1093","volume":"76","author":[{"given":"Meriam","family":"Ben Said","sequence":"first","affiliation":[{"name":"Tunisian Institute of Veterinary Research, University of Tunis El Manar , 20 street Jebel Lakhdhar, Tunis 1006 , Tunisia"},{"name":"\u00c1rea de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de La Rioja , Madre de Dios 51, 26006 Logro\u00f1o, La Rioja , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamia","family":"Thabet","sequence":"additional","affiliation":[{"name":"Research Laboratory \u2018Antimicrobial Resistance LR99ES09\u2019, Faculty de Medecine of Tunis, University of Tunis El Manar , 15 Rue Djebel Akhdhar, La Rabta, Tunis 1006 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Cheriet","sequence":"additional","affiliation":[{"name":"Tunisian Institute of Veterinary Research, University of Tunis El Manar , 20 street Jebel Lakhdhar, Tunis 1006 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amen Allah","family":"Messadi","sequence":"additional","affiliation":[{"name":"Research Laboratory \u2018Antimicrobial Resistance LR99ES09\u2019, Faculty de Medecine of Tunis, University of Tunis El Manar , 15 Rue Djebel Akhdhar, La Rabta, Tunis 1006 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Centre de Recherche et des Technologies des Eaux (CERTE), Laboratoire de Traitement et de Valorisation des rejets hydriques , Technopole Borj-C\u00e9dria, BP 273, Soliman 8020 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ruiz-Ripa","sequence":"additional","affiliation":[{"name":"Centre de Recherche et des Technologies des Eaux (CERTE), Laboratoire de Traitement et de Valorisation des rejets hydriques , Technopole Borj-C\u00e9dria, BP 273, Soliman 8020 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senda","family":"Sghaier","sequence":"additional","affiliation":[{"name":"Tunisian Institute of Veterinary Research, University of Tunis El Manar , 20 street Jebel Lakhdhar, Tunis 1006 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilel","family":"Hassen","sequence":"additional","affiliation":[{"name":"Tunisian Institute of Veterinary Research, University of Tunis El Manar , 20 street Jebel Lakhdhar, Tunis 1006 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdennaceur","family":"Hassen","sequence":"additional","affiliation":[{"name":"\u00c1rea de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de La Rioja , Madre de Dios 51, 26006 Logro\u00f1o, La Rioja , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-1690","authenticated-orcid":false,"given":"Carmen","family":"Torres","sequence":"additional","affiliation":[{"name":"Research Laboratory \u2018Antimicrobial Resistance LR99ES09\u2019, Faculty de Medecine of Tunis, University of Tunis El Manar , 15 Rue Djebel Akhdhar, La Rabta, Tunis 1006 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9673-193X","authenticated-orcid":false,"given":"Mohamed Salah","family":"Abbassi","sequence":"additional","affiliation":[{"name":"Tunisian Institute of Veterinary Research, University of Tunis El Manar , 20 street Jebel Lakhdhar, Tunis 1006 , Tunisia"},{"name":"Laboratoire de Biologie m\u00e9dicale et Banque du Sang , Centre de Traumatologie et des grands Br\u00fbl\u00e9s Ben, Arous 97475 , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"2024040813405862600_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/1658-631X.170880","article-title":"Methicillin-resistant Staphylococcus aureus in Saudi Arabia: genotypes distribution review","volume":"4","author":"Al\u00a0Yousef","year":"2016","journal-title":"Saudi\u00a0J Med Med Sci"},{"key":"2024040813405862600_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/antibiotics8010026","article-title":"Genetic profiling and comparison of human and animal methicillin-resistant Staphylococcus aureus (MRSA) isolates from 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