{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:48:19Z","timestamp":1784141299312,"version":"3.55.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["K19K05799"],"award-info":[{"award-number":["K19K05799"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07029"],"award-info":[{"award-number":["21K07029"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug resistance commonly occurs when treating immunocompromized patients with fungal infections. Dehydrozingerone\u2014a phenolic compound isolated from the rhizome of Zingiber officinale\u2014inhibits drug efflux in Saccharomyces cerevisiae by overexpression of the ATP-binding cassette (ABC) transporter Pdr5p. We aimed to investigate whether dehydrozingerone enhances the antifungal activity of glabridin\u2014an isoflavan isolated from the roots of Glycyrrhiza glabra L.\u2014by attenuating multidrug resistance through the intrinsic expression system of multidrug-efflux-related genes in a wild-type strain of the model yeast. The antifungal activity of 50\u00a0\u03bcmol l\u22121 glabridin alone was weak and temporary against S. cerevisiae; however, cell viability was significantly inhibited when the cells were co-treated with glabridin and dehydrozingerone. This enhancement was also observed in human pathogenic Candida albicans. Glabridin efflux did not depend on a particular drug efflux pump; instead, the transcription factors PDR1 and PDR3\u2014regulating the transcription of multiple genes encoding drug efflux pumps\u2014were involved in the antifungal activity and efflux of glabridin. qRT\u2013PCR analysis revealed that dehydrozingerone reduced glabridin-induced overexpression of the ABC transporter-related genes PDR1, PDR3, and PDR5 to the levels observed in untreated cells. Our findings indicated that dehydrozingerone potentiates the efficacy of plant-derived antifungals through its effects on ABC transporters.<\/jats:p>","DOI":"10.1093\/lambio\/ovad040","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T10:50:35Z","timestamp":1680951035000},"source":"Crossref","is-referenced-by-count":5,"title":["Dehydrozingerone enhances the fungicidal activity of glabridin against<i>Saccharomyces cerevisiae<\/i>and<i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"76","author":[{"given":"Saya","family":"Yamano","sequence":"first","affiliation":[{"name":"Graduate School of Science, Osaka Metropolitan University , 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Tsukuda","sequence":"additional","affiliation":[{"name":"Graduate School of Science, Osaka Metropolitan University , 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Mizuhara","sequence":"additional","affiliation":[{"name":"Graduate School of Science, Osaka Metropolitan University , 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Graduate School of Science, Osaka Metropolitan University , 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ogita","sequence":"additional","affiliation":[{"name":"Graduate School of Science, Osaka Metropolitan University , 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 , Japan"},{"name":"Research Center for Urban Health and Sports, Osaka Metropolitan University , 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 , 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