{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:57:39Z","timestamp":1770742659601,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012725","name":"Tecnol\u00f3gico Nacional de M\u00e9xico","doi-asserted-by":"publisher","award":["7805.20-P"],"award-info":[{"award-number":["7805.20-P"]}],"id":[{"id":"10.13039\/100012725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This research aimed to evaluate the antimicrobial activity of essential oils (EOs) against clinically and environmentally isolated Salmonella serotypes. Oregano, thyme, and grapefruit EO compounds were identified, and the antimicrobial activity was evaluated against the S. Saintpaul, Oranienburg, and Infantis serotypes. In addition, molecular docking was performed to explore the possible mechanisms between compounds of EOs with microbial enzymes. Thymol was the main compound identified in oregano (44.0%) and thyme (31%) EOs, while d-limonene was present in a greater proportion in grapefruit EO. Oregano EO had the highest antimicrobial activity, followed by thyme and grapefruit EOs. Oregano and thyme EOs illustrated a greater inhibitory capacity to all serotypes, particularly with the environmental S. Saintpaul. Oregano EO presented values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration of 0.1\u2009\u03bcL\/mL for all serotypes, while thyme and grapefruit EOs presented MIC values of 0.1\u2009\u03bcL\/mL for the clinical serotypes S. Infantis and S. Oranienburg, respectively. Molecular docking analysis showed the optimal binding free energies for thymol and carvacrol with glucokinase, ATP-dependent-6-fructokinase, outer membrane porin C, and topoisomerase IV. Our results indicate that these EOs can inhibit clinically and environmentally isolated Salmonella serotypes and can be used as alternatives for developing natural food preservatives.<\/jats:p>","DOI":"10.1093\/lambio\/ovad045","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T02:15:52Z","timestamp":1681438552000},"source":"Crossref","is-referenced-by-count":10,"title":["Activity of plant essential oils against clinically and environmentally isolated<i>Salmonella enterica<\/i>serotypes:<i>in vitro<\/i>assays and molecular docking"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-2792","authenticated-orcid":false,"given":"Jes\u00fas J","family":"Roch\u00edn-Medina","sequence":"first","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Molecular y Bioactivos, Tecnol\u00f3gico Nacional de M\u00e9xico-Instituto Tecnol\u00f3gico de Culiac\u00e1n , 80220 Culiac\u00e1n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilianne A","family":"Mendoza-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Molecular y Bioactivos, Tecnol\u00f3gico Nacional de M\u00e9xico-Instituto Tecnol\u00f3gico de Culiac\u00e1n , 80220 Culiac\u00e1n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0738-492X","authenticated-orcid":false,"given":"Nohelia","family":"Castro-del\u00a0Campo","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional para la Investigaci\u00f3n en Inocuidad Alimentaria, Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo A.C. , 80110 Culiac\u00e1n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro J","family":"Bastidas-Bastidas","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional para la Investigaci\u00f3n en Inocuidad Alimentaria, Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo A.C. , 80110 Culiac\u00e1n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-992X","authenticated-orcid":false,"given":"Karina","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Molecular y Bioactivos, Tecnol\u00f3gico Nacional de M\u00e9xico-Instituto Tecnol\u00f3gico de Culiac\u00e1n , 80220 Culiac\u00e1n , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"2023041714553656500_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13099-021-00443-3","article-title":"In silico molecular docking and in vitro antimicrobial efficacy of phytochemicals against multi-drug-resistant enteroaggregative Escherichia coli and non-typhoidal Salmonella spp","volume":"13","author":"Abishad","year":"2021","journal-title":"Gut 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