{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:45:26Z","timestamp":1790617526505,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Government of India","doi-asserted-by":"publisher","award":["IASST\/R&D\/LSD\/IHP-06\/2023\u201324\/1284\u20131291"],"award-info":[{"award-number":["IASST\/R&D\/LSD\/IHP-06\/2023\u201324\/1284\u20131291"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study reports the isolation and characterization of a Streptomyces sp. from soil, capable of producing bioactive secondary metabolites active against a variety of bacterial human pathogens. We targeted the antimicrobial activity against Escherichia coli ATCC-BAA 2469, a clinically relevant strain of bacteria harbouring resistance genes for carbapenems, extended spectrum beta-lactams, tetracyclines, fluoroquinones, etc. Preliminary screening using the spot inoculation technique identified Streptomyces sp. NP73 as the potent strain among the 74 isolated Actinomycetia strain. 16S rRNA gene and whole genome sequencing (WGS) confirmed its taxonomical identity and helped in the construction of the phylogenetic tree. WGS revealed the predicted pathways and biosynthetic gene clusters responsible for producing various types of antibiotics including the isolated compound. Bioactivity guided fractionation and chemical characterization of the active fraction, carried out using liquid chromatography, gas chromatography-mass spectrometry, infra-red spectroscopy, and nuclear magnetic resonance spectroscopy, led to the tentative identification of the active compound as Pyrrolo[1,2-a] pyrazine-1,4-dione, hexahydro-, a diketopiperazine molecule. This compound exhibited excellent antimicrobial and anti-biofilm properties against E. coli ATCC-BAA 2469 with an MIC value of 15.64\u00a0\u00b5g ml\u22121, and the low cytotoxicity of the compound identified in this study provides hope for future drug development.<\/jats:p>","DOI":"10.1093\/lambio\/ovae086","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T08:53:29Z","timestamp":1725958409000},"source":"Crossref","is-referenced-by-count":6,"title":["Antimicrobial potential of\n                    <i>Streptomyces<\/i>\n                    sp. NP73 isolated from the forest soil of Northeast India against multi-drug resistant\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"77","author":[{"given":"Aditya Narayan","family":"Konwar","sequence":"first","affiliation":[{"name":"Microbial Biotechnology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology , Guwahati, Assam 781035 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201002 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Basak","sequence":"additional","affiliation":[{"name":"Microbial Biotechnology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology , Guwahati, Assam 781035 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201002 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangkon","family":"Saikia","sequence":"additional","affiliation":[{"name":"Bioinformatics Infrastructure Facility, Institute of Advanced Study in Science and Technology , Guwahati , Assam 781035,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Gurumayum","sequence":"additional","affiliation":[{"name":"Chemical Biology Laboratory-1, Life Sciences Division, Institute of Advanced Study in Science and Technology , Guwahati, Assam 781035 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitya","family":"Panthi","sequence":"additional","affiliation":[{"name":"Microbial Biotechnology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology , Guwahati, Assam 781035 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagat Chandra","family":"Borah","sequence":"additional","affiliation":[{"name":"Chemical Biology Laboratory-1, Life Sciences Division, Institute of Advanced Study in Science and Technology , Guwahati, Assam 781035 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debajit","family":"Thakur","sequence":"additional","affiliation":[{"name":"Microbial Biotechnology Laboratory, Life Sciences Division, Institute of Advanced Study in Science and Technology , Guwahati, Assam 781035 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201002 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"2024122308404032700_bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1307801","article-title":"Anti-biofilm, antibacterial, and anti-quorum sensing activities of selected South African plants traditionally used to treat diarrhoea","volume":"2022","author":"Adeyemo","year":"2022","journal-title":"Evid-Based Complement Altern Med"},{"key":"2024122308404032700_bib2","doi-asserted-by":"publisher","first-page":"15233","DOI":"10.1039\/C4RA15710A","article-title":"Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics","volume":"5","author":"Bhardwaj","year":"2015","journal-title":"RSC Adv"},{"key":"2024122308404032700_bib3","doi-asserted-by":"publisher","first-page":"W29","DOI":"10.1093\/nar\/gkab335","article-title":"AntiSMASH 6.0: improving cluster detection and comparison capabilities","volume":"49","author":"Blin","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024122308404032700_bib4","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1039\/C8OB03063D","article-title":"The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases","volume":"17","author":"Borgman","year":"2019","journal-title":"Org Biomol Chem"},{"key":"2024122308404032700_bib5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.procbio.2022.03.010","article-title":"Streptomyces filamentosus strain KS17 isolated from microbiologically unexplored marine ecosystems exhibited a broad spectrum of antimicrobial activity against human pathogens","volume":"117","author":"Chakraborty","year":"2022","journal-title":"Process Biochem"},{"key":"2024122308404032700_bib6","doi-asserted-by":"publisher","first-page":"S233","DOI":"10.1542\/peds.2008-1285c","article-title":"Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators","volume":"122","author":"Chesney","year":"2008","journal-title":"Pediatrics"},{"key":"2024122308404032700_bib7","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/cbic.200300583","article-title":"The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization","volume":"4","author":"Cone","year":"2003","journal-title":"ChemBioChem"},{"key":"2024122308404032700_bib56","article-title":"M02Ed13 | Performance Standards for Antimicrobial Disk Susceptibility Tests","author":"CLSI","year":"2023","edition":"13th Edition"},{"key":"2024122308404032700_bib57","article-title":"M07: dilution AST for aerobically grown bacteria\u2014CLSI","author":"CLSI","year":"2023"},{"key":"2024122308404032700_bib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-21249-5","article-title":"Streptomyces sp metabolite(s) promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines","volume":"8","author":"Dan","year":"2018","journal-title":"Sci Rep"},{"key":"2024122308404032700_bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-14549-4","article-title":"An antibacterial compound pyrimidomycin produced by Streptomyces sp. PSAA01 isolated from soil of Eastern Himalayan foothill","volume":"12","author":"Das","year":"2022","journal-title":"Sci Rep"},{"key":"2024122308404032700_bib10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12866-018-1215-7","article-title":"Antimicrobial potentiality of actinobacteria isolated from two microbiologically unexplored forest ecosystems of Northeast India","volume":"18","author":"Das","year":"2018","journal-title":"BMC Microbiol"},{"key":"2024122308404032700_bib11","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3390\/antibiotics10050483","article-title":"Actinomycetes: a never-ending source of bioactive compounds\u2014an overview on antibiotics production","volume":"10","author":"De\u00a0Simeis","year":"2021","journal-title":"Antibiotics"},{"key":"2024122308404032700_bib12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep32926","article-title":"Purification, characterization, cytotoxicity and anticancer activities of L-asparaginase, anti-colon cancer protein, from the newly isolated alkaliphilic Streptomyces fradiae NEAE-82","volume":"6","author":"El-Naggar","year":"2016","journal-title":"Sci Rep"},{"key":"2024122308404032700_bib13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s44259-023-00020-5","article-title":"History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome","volume":"2","author":"Franck","year":"2024","journal-title":"NPJ Antimicrob Resist"},{"key":"2024122308404032700_bib14","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1128\/am.13.6.935-938.1965","article-title":"Geosmin, an earthy-smelling substance isolated from actinomycetes","volume":"13","author":"Gerber","year":"1965","journal-title":"Appl Microbiol"},{"key":"2024122308404032700_bib15","doi-asserted-by":"publisher","first-page":"e1000339","DOI":"10.1371\/journal.pbio.1000339","article-title":"Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights","volume":"8","author":"Goto","year":"2010","journal-title":"PLoS Biol"},{"key":"2024122308404032700_bib16","first-page":"096","article-title":"Plant growth promoting rhizobacteria (PGPR): current and future prospects for development of sustainable agriculture","volume":"7","author":"Gupta","year":"2015","journal-title":"J Microb Biochem Technol"},{"key":"2024122308404032700_bib17","doi-asserted-by":"publisher","first-page":"115936","DOI":"10.1016\/j.jep.2022.115936","article-title":"Taxifolin-3-O-glucoside from Osbeckia nepalensis Hook. mediates antihyperglycemic activity in CC1 hepatocytes and in diabetic Wistar rats via regulating AMPK\/G6Pase\/PEPCK signaling axis","volume":"303","author":"Gurumayum","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"2024122308404032700_bib18","doi-asserted-by":"publisher","first-page":"738058","DOI":"10.3389\/fmicb.2021.738058","article-title":"Prospecting endophytic bacteria endowed with plant growth promoting potential isolated from Camellia sinensis","volume":"12","author":"Hazarika","year":"2021","journal-title":"Front Microbiol"},{"key":"2024122308404032700_bib19","first-page":"1","article-title":"Kirby\u2013Bauer disk diffusion susceptibility test protocol","volume":"1","author":"Hudzicki","year":"2009","journal-title":"Am Soc Microbiol"},{"key":"2024122308404032700_bib20","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.7164\/antibiotics.41.1711","article-title":"Nucleoside antibiotics: structure, biological activity, and biosynthesis","volume":"41","author":"Isono","year":"1988","journal-title":"J Antibiot"},{"key":"2024122308404032700_bib21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-07641-9","article-title":"High throughput ANI analysis of 90\u00a0K prokaryotic genomes reveals clear species boundaries","volume":"9","author":"Jain","year":"2018","journal-title":"Nat Commun"},{"key":"2024122308404032700_bib22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3947\/ic.2018.50.1.67","article-title":"Clinical practice guidelines for the antibiotic treatment of community-acquired urinary tract infections","volume":"33","author":"Kang","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2024122308404032700_bib23","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1093\/NAR\/GKI198","article-title":"MAFFT version 5: improvement in accuracy of multiple sequence alignment","volume":"33","author":"Katoh","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2024122308404032700_bib24","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1542\/peds.2015-0409","article-title":"Risk factors for recurrent urinary tract infection and renal scarring","volume":"136","author":"Keren","year":"2015","journal-title":"Pediatrics"},{"key":"2024122308404032700_bib25","doi-asserted-by":"publisher","first-page":"17837","DOI":"10.1039\/C8RA00820E","article-title":"An antibiotic agent pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro isolated from a marine bacteria Bacillus tequilensis MSI45 effectively controls multi-drug resistant Staphylococcus aureus","volume":"8","author":"Kiran","year":"2018","journal-title":"RSC Adv"},{"key":"2024122308404032700_bib26","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s13205-023-03670-4","article-title":"Streptomyces sp. MNP32, a forest-dwelling Actinomycetia endowed with potent antibacterial metabolites","volume":"13","author":"Konwar","year":"2023","journal-title":"3 Biotech"},{"key":"2024122308404032700_bib27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00253-013-5373-0","article-title":"Intriguing properties of the angucycline antibiotic auricin and complex regulation of its biosynthesis","volume":"98","author":"Kormanec","year":"2014","journal-title":"Appl Microbiol Biotechnol"},{"key":"2024122308404032700_bib28","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1007\/s10495-016-1221-x","article-title":"Anticancer potential of pyrrole (1, 2, a) pyrazine 1, 4, dione, hexahydro 3-(2-methyl propyl) (PPDHMP) extracted from a new marine bacterium, Staphylococcus sp. strain MB30","volume":"21","author":"Lalitha","year":"2016","journal-title":"Apoptosis"},{"key":"2024122308404032700_bib29","first-page":"11","article-title":"Soil quality of Northeast India-a review","volume":"10","author":"Lalmuansangi","year":"2022","journal-title":"Int J Res Eng Sci"},{"key":"2024122308404032700_bib30","doi-asserted-by":"publisher","first-page":"D1020","DOI":"10.1093\/nar\/gkaa1105","article-title":"RefSeq: expanding the Prokaryotic Genome Annotation Pipeline reach with protein family model curation","volume":"49","author":"Li","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024122308404032700_bib31","doi-asserted-by":"publisher","first-page":"e03489","DOI":"10.1128\/spectrum.03489-22","article-title":"Streptomyces sp. strain PBR11, a forest-derived soil Actinomycetia with antimicrobial potential","volume":"11","author":"Mazumdar","year":"2023","journal-title":"Microbiol Spectr"},{"key":"2024122308404032700_bib32","first-page":"1","article-title":"Antibacterial activity and biosynthetic potential of Streptomyces sp. PBR19, isolated from forest rhizosphere soil of Assam","volume":"10","author":"Mazumdar","year":"2024","journal-title":"Braz J Microbiol"},{"key":"2024122308404032700_bib33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/microbiolspec.DMIH2-0021-2015","article-title":"Aerobic actinomycetes of clinical significance","volume":"4","author":"Mochon","year":"2016","journal-title":"Microbiol Spectr"},{"key":"2024122308404032700_bib34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.btre.2016.06.001","article-title":"Antimicrobial activities of secondary metabolites and phylogenetic study of sponge endosymbiotic bacteria, Bacillus sp. at Agatti Island, Lakshadweep Archipelago","volume":"11","author":"Mohan","year":"2016","journal-title":"Biotechnology Reports"},{"key":"2024122308404032700_bib35","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.1021\/acs.chemrev.6b00523","article-title":"Aminoacyl-tRNA-utilizing enzymes in natural product biosynthesis","volume":"117","author":"Moutiez","year":"2017","journal-title":"Chem Rev"},{"key":"2024122308404032700_bib36","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.medmal.2011.07.005","article-title":"French results of the ARESC Study: clinical aspects and epidemiology of antimicrobial resistance in female patients with cystitis. Implications for empiric therapy","volume":"42","author":"Neuzillet","year":"2012","journal-title":"M\u00e9d Mal Infect"},{"key":"2024122308404032700_bib37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1039\/C6MB00675B","article-title":"Diversity of nature's assembly lines\u2014recent discoveries in non-ribosomal peptide synthesis","volume":"13","author":"Payne","year":"2017","journal-title":"Mol BioSyst"},{"key":"2024122308404032700_bib38","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.tiv.2007.03.001","article-title":"Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines","volume":"21","author":"Peyrou","year":"2007","journal-title":"Toxicol in Vitro"},{"key":"2024122308404032700_bib39","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.micpath.2018.03.011","article-title":"Antibiofilm effect of Nocardiopsis sp. GRG 1 (KT235640) compound against biofilm forming Gram negative bacteria on UTIs","volume":"118","author":"Rajivgandhi","year":"2018","journal-title":"Microb Pathog"},{"key":"2024122308404032700_bib40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-45060-y","article-title":"Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients","volume":"9","author":"Ramos-Vivas","year":"2019","journal-title":"Sci Rep"},{"key":"2024122308404032700_bib41","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/nyas.13598","article-title":"The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics","volume":"1435","author":"Richter","year":"2019","journal-title":"Ann NY Acad Sci"},{"key":"2024122308404032700_bib42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.22377\/AJP.V10I04.865","article-title":"Bioactivity of Pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(phenylmethyl)- extracted from Streptomyces sp. VITPK9 isolated from the Salt Spring Habitat of Manipur, India","volume":"10","author":"Sanjenbam","year":"2016","journal-title":"Asian J Pharm"},{"key":"2024122308404032700_bib43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2016.00347","article-title":"Broad spectrum antimicrobial activity of forest-derived soil actinomycete, Nocardia sp. PB-52","volume":"7","author":"Sharma","year":"2016","journal-title":"Front Microbiol"},{"key":"2024122308404032700_bib44","doi-asserted-by":"publisher","first-page":"427","DOI":"10.7164\/antibiotics.32.427","article-title":"Studies on Actinomycetales producing antibiotics only on agar culture. I. Screening, taxonomy and morphology-productivity relationship of Streptomyces halstedii, strain SF-1993","volume":"32","author":"Shomura","year":"1979","journal-title":"J Antibiot"},{"key":"2024122308404032700_bib58_259_131024","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3389\/fmicb.2019.01269","article-title":"3-Benzyl-Hexahydro-Pyrrolo[1,2-a]Pyrazine-1,4-Dione Extracted From Exiguobacterium indicum Showed Anti-biofilm Activity Against Pseudomonas aeruginosa by Attenuating Quorum Sensing","volume":"10","author":"Singh","year":"2019","journal-title":"Front Microbiol"},{"key":"2024122308404032700_bib45","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies","volume":"30","author":"Stamatakis","year":"2014","journal-title":"Bioinformatics"},{"key":"2024122308404032700_bib46","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1038\/nprot.2014.093","article-title":"Antibiotic resistance-mediated isolation of scaffold-specific natural product producers","volume":"9","author":"Thaker","year":"2014","journal-title":"Nat Protoc"},{"key":"2024122308404032700_bib47","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.mycmed.2007.08.001","article-title":"Isolation and screening of Streptomyces in soil of protected forest areas from the states of Assam and Tripura, India, for antimicrobial metabolites","volume":"17","author":"Thakur","year":"2007","journal-title":"J Mycol M\u00e9d"},{"key":"2024122308404032700_bib48","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.20546\/ijcmas.2018.707.335","article-title":"Characterization of soils of lower Dibang Valley District of Arunachal Pradesh, North East India","volume":"7","author":"Thungon","year":"2018","journal-title":"Int J Curr Microbiol App Sci"},{"key":"2024122308404032700_bib49","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/S00203-017-1417-7\/FIGURES\/13","article-title":"Bioprospecting marine actinomycetes for multidrug-resistant pathogen control from Rameswaram coastal area, Tamil Nadu, India","volume":"200","author":"Wahaab","year":"2018","journal-title":"Arch Microbiol"},{"key":"2024122308404032700_bib50","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1469-0691.2005.01264.x","article-title":"The emergence and implications of metallo-\u03b2-lactamases in Gram-negative bacteria","volume":"11","author":"Walsh","year":"2005","journal-title":"Clin Microbiol Infect"},{"key":"2024122308404032700_bib51","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1128\/jb.173.2.697-703.1991","article-title":"16S ribosomal DNA amplification for phylogenetic study","volume":"173","author":"Weisburg","year":"1991","journal-title":"J Bacteriol"},{"key":"2024122308404032700_bib52","doi-asserted-by":"publisher","first-page":"e1005595","DOI":"10.1371\/journal.pcbi.1005595","article-title":"Unicycler: resolving bacterial genome assemblies from short and long sequencing reads","volume":"13","author":"Wick","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"2024122308404032700_bib53","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.ijantimicag.2011.04.021","article-title":"Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates","volume":"38","author":"Yang","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"2024122308404032700_bib54","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jgar.2023.03.011","article-title":"Co-occurrence of blaNDM-1, rmtC, and mcr-9 in multidrug-resistant Enterobacter kobei strain isolated from an infant with urinary tract infection","volume":"33","author":"Zeng","year":"2023","journal-title":"J Global Antimicrob Resist"},{"key":"2024122308404032700_bib55","doi-asserted-by":"publisher","first-page":"104196","DOI":"10.1016\/j.micpath.2020.104196","article-title":"A systematic review and meta-analysis of antibiotic resistance patterns, and the correlation between biofilm formation with virulence factors in uropathogenic E. coli isolated from urinary tract infections","volume":"144","author":"Zhao","year":"2020","journal-title":"Microb Pathog"}],"container-title":["Letters in Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lambio\/advance-article-pdf\/doi\/10.1093\/lambio\/ovae086\/59090365\/ovae086.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/77\/9\/ovae086\/59200647\/ovae086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/77\/9\/ovae086\/59200647\/ovae086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T03:40:53Z","timestamp":1734925253000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lambio\/article\/doi\/10.1093\/lambio\/ovae086\/7755411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/lambio\/ovae086","relation":{},"ISSN":["1472-765X"],"issn-type":[{"value":"1472-765X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,9]]},"article-number":"ovae086"}}