{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:02:06Z","timestamp":1792450926677,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Government of India","doi-asserted-by":"publisher","award":["SB\/YS\/LS-98\/2014"],"award-info":[{"award-number":["SB\/YS\/LS-98\/2014"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EEQ\/2017\/000496"],"award-info":[{"award-number":["EEQ\/2017\/000496"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) has become one of the most serious threats to One Health. Aquatic environments are an ideal non-clinical AMR reservoir and can act as a key battlefront for tackling the AMR. However, AMR data using the One Health approach remain scarce in aquatic environments worldwide. Here, we extensively assessed AMR in Escherichia coli isolated from urban and rural lake ecosystems using the One Health perspective. A total of 162 E. coli isolates obtained from lakes were tested against 25 antimicrobials using an in-vitro antimicrobial susceptibility testing method. A low (2%) to moderate (45%) drug resistance rate was found for all antimicrobials used in human\/veterinary medicine or animal\/plant agriculture. However, &amp;lt;80% E. coli isolates exhibited multidrug resistance (MDR) phenotype to highly important (amikacin, gentamicin, trimethoprim) or critically important (amoxicillin, ampicillin, colistin) drugs of both human and veterinary medicine. Of concern, &amp;gt;50% of E. coli isolates exhibited MDR to drugs used as last-resorts (chloramphenicol, colistin) or as frontline (nitrofurantoin, sulfamethoxazole, ampicillin, gentamicin) against E. coli infections. In conclusion, the presence of MDR E. coli strains in urban or rural lake ecosystems highlights their possible role as AMR reservoirs with potential One Health risks.<\/jats:p>","DOI":"10.1093\/lambio\/ovae095","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T15:20:27Z","timestamp":1727968827000},"source":"Crossref","is-referenced-by-count":4,"title":["A One Health exploration of antimicrobial resistance in\n                    <i>Escherichia coli<\/i>\n                    originated from urban and rural lakes ecosystem"],"prefix":"10.1093","volume":"77","author":[{"given":"Priyanka","family":"Priyanka","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Central University of Rajasthan , Ajmer, 305817 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem Raj","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Central University of Rajasthan , Ajmer, 305817 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharma","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, ICMR-National Institute for Research in Environmental Health , Bhopal, 462030 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Central University of Rajasthan , Ajmer, 305817 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand Kumar","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Central University of Rajasthan , Ajmer, 305817 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Siddaardha","family":"Duggirala","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Central University of Rajasthan , Ajmer, 305817 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Dhanokar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Central University of Rajasthan , Ajmer, 305817 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, Central University of Rajasthan , Ajmer, 305817 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Sciences & Humanities, Chaudhary Charan Singh Haryana Agricultural University , Hisar, 125004 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6822-6469","authenticated-orcid":false,"given":"Arvind Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Jawaharlal Nehru University , New Delhi, Delhi, 110067 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"2024102212315064300_bib1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.mib.2021.09.011","article-title":"The potential of using E. coli as an indicator for the surveillance of antimicrobial resistance (AMR) in the environment","volume":"64","author":"Anjum","year":"2021","journal-title":"Curr Opin Microbiol"},{"key":"2024102212315064300_bib2","doi-asserted-by":"publisher","first-page":"154890","DOI":"10.1016\/j.scitotenv.2022.154890","article-title":"Spatiotemporal distribution of 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