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As recent evidence suggests that wildlife can play a role in the dissemination of bacterial resistomes, this study explored the potential role of Algerian wild birds as a reservoir of VRE. A total of 222 cloacal and fecal samples were collected from various wild bird species and screened for VRE using a selective medium. Of the 47 isolated strains, 22 were identified as Enterococcus casseliflavus with the vanC2\/C3 gene, 24 as Enterococcus gallinarum (19 carrying vanC1 and five carrying vanC2\/C3), and one strain as Enterococcus faecalis with the vanC1 gene. Twenty-four (24) strains were multidrug-resistant with 61.7% resistant to rifampicin, while no resistance to teicoplanin, linezolid, and gentamicin was found. Additionally, 53.20% of the strains exhibited at least one virulence factor. To our knowledge, this study represents the first documentation of the vanC1 gene in E. faecalis isolated from wild birds. Furthermore, this gene was found to be carried by a conjugative plasmid, highlighting its ability to spread among bacterial populations and lead to the emergence of novel resistance phenotypes.<\/jats:p>","DOI":"10.1093\/lambio\/ovae098","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T04:04:03Z","timestamp":1728705843000},"source":"Crossref","is-referenced-by-count":2,"title":["Phenotypic and molecular characterization of vancomycin resistant enterococci from wild birds: first detection of a plasmid-borne <i>van<\/i>C1 in <i>Enterococcus faecalis<\/i>"],"prefix":"10.1093","volume":"77","author":[{"given":"Yousra","family":"Hachem","sequence":"first","affiliation":[{"name":"Microbiology Group, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology-Houari Boumediene , 16111 Bab-Ezzouar, Algiers ,","place":["Algeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-2926","authenticated-orcid":false,"given":"Lydia Neila","family":"Djouadi","sequence":"additional","affiliation":[{"name":"Microbiology Group, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology-Houari Boumediene , 16111 Bab-Ezzouar, Algiers ,","place":["Algeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-9735","authenticated-orcid":false,"given":"Anis","family":"Raddaoui","sequence":"additional","affiliation":[{"name":"Laboratory Ward, National Bone Marrow Transplant Center , 1006 Tunis ,","place":["Tunisia"]},{"name":"Faculty of Medicine of Tunis, LR18ES39, University of Tunis El Manar , 1006 Tunis ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fella","family":"Boukli-Hacene","sequence":"additional","affiliation":[{"name":"Microbiology Group, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology-Houari Boumediene , 16111 Bab-Ezzouar, Algiers ,","place":["Algeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanane","family":"Boumerdassi","sequence":"additional","affiliation":[{"name":"Microbiology Group, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology-Houari Boumediene , 16111 Bab-Ezzouar, Algiers ,","place":["Algeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Achour","sequence":"additional","affiliation":[{"name":"Laboratory Ward, National Bone Marrow Transplant Center , 1006 Tunis ,","place":["Tunisia"]},{"name":"Faculty of Medicine of Tunis, LR18ES39, University of Tunis El Manar , 1006 Tunis ,","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farida","family":"Nateche","sequence":"additional","affiliation":[{"name":"Microbiology Group, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology-Houari Boumediene , 16111 Bab-Ezzouar, Algiers ,","place":["Algeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"2024102109260926600_bib1","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.ijantimicag.2007.01.006","article-title":"High-level gentamicin-resistant Enterococcus faecium strains isolated from bone marrow transplant patients: accumulation of antibiotic resistance genes, large plasmids and clonal strain dissemination","volume":"29","author":"Abbassi","year":"2007","journal-title":"Int J Antimicrob Agents"},{"key":"2024102109260926600_bib2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.medmal.2008.05.003","article-title":"First case of vancomycin-resistant Enterococcus faecalis in Algeria. 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