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This mini-review emphasis on the microbial production of GABA and its potential benefits in various applications. Numerous microorganisms, including lactic acid bacteria, have been identified as efficient GABA producers. These microbes utilize glutamate decarboxylase enzymes to convert L-glutamate to GABA. Notable GABA-producing strains include Lactobacillus brevis, Lactobacillus plantarum, and certain Bifidobacterium species. Microbial GABA production offers numerous benefits over chemical synthesis, including cost-effectiveness, sustainability, and the potential for in situ production in fermented foods. Recent research has optimized fermentation conditions, genetic engineering approaches, and substrate utilization to enhance GABA yields. The benefits of GABA extend beyond its neurotransmitter role. Studies have shown its potential to reduce blood pressure, assuage anxiety, improve sleep quality, and improve cognitive function. These properties make microbial GABA production particularly attractive for developing functional foods, nutraceuticals, and pharmaceuticals. Future research directions include exploring novel GABA-producing strains, improving production efficiency, and investigating additional health benefits of microbially produced GABA.<\/jats:p>","DOI":"10.1093\/lambio\/ovae122","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T09:07:17Z","timestamp":1734167237000},"source":"Crossref","is-referenced-by-count":33,"title":["Microbial gamma-aminobutyric acid synthesis: a promising approach for functional food and pharmaceutical applications"],"prefix":"10.1093","volume":"77","author":[{"given":"Racheal Oluwayemisi","family":"Fashogbon","sequence":"first","affiliation":[{"name":"Department of Microbiology and Biotechnology, Faculty of Natural Sciences, Ajayi Crowther University , Oyo, P.M.B. 1066 ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyindamola John","family":"Samson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology, Faculty of Natural Sciences, Ajayi Crowther University , Oyo, P.M.B. 1066 ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa Abimbola","family":"Awotundun","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology, Faculty of Natural Sciences, Ajayi Crowther University , Oyo, P.M.B. 1066 ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afolake Atinuke","family":"Olanbiwoninu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology, Faculty of Natural Sciences, Ajayi Crowther University , Oyo, P.M.B. 1066 ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bukola Christiana","family":"Adebayo-Tayo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science, University of Ibadan , Oyo , POBox 200005,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"2025010217200710200_bib3","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1177\/02698811231161579","article-title":"Effects of gamma-aminobutyric acid on working memory and attention: a randomized, double-blinded, placebo-controlled, crossover trial","volume":"37","author":"Al\u00a0t\u0131nok","year":"2023","journal-title":"J Psychopharmacol"},{"key":"2025010217200710200_bib2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3390\/nutraceuticals4020015","article-title":"The effect of oral GABA on the nervous system: potential for therapeutic intervention","volume":"4","author":"Almutairi","year":"2024","journal-title":"Nutraceuticals"},{"key":"2025010217200710200_bib4","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1002\/bit.28103","article-title":"Pareto optimal metabolic engineering for the growth-coupled overproduction of sustainable chemicals","volume":"119","author":"Amaradio","year":"2022","journal-title":"Biotechnol Bioeng"},{"key":"2025010217200710200_bib5","doi-asserted-by":"publisher","first-page":"108654","DOI":"10.1016\/j.bej.2022.108654","article-title":"Production of gamma-aminobutyric acid (GABA) by Bacillus subtilis BBEL02 fermentation using nitrogen-rich industrial wastes as crude feedstocks","volume":"187","author":"Asun","year":"2022","journal-title":"Biochem Eng J"},{"key":"2025010217200710200_bib6","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3390\/antiox13060647","article-title":"Evaluation of gamma-aminobutyric acid (GABA) as a functional feed ingredient on growth performance, immune enhancement, and disease resistance in olive flounder (Paralichthys olivaceus) under high stocking density","volume":"13","author":"Bae","year":"2024","journal-title":"Antioxidants"},{"key":"2025010217200710200_bib7","doi-asserted-by":"publisher","DOI":"10.1007\/698_2023_1064","article-title":"Drivers for efficient bioaugmentation and clean-up of contaminated soil","volume-title":"Soil Remediation Science and Technology. 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