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Therefore, we examined whether probiotics Lactococcus lactis P135 and Bifidobacterium longum P142, which inhibited HP growth by 37.9% and 35.3%, respectively, and HP-induced IL-8 expression in KATO III cells by 68.6% and 63.1%, respectively, compared to those of normal controls, could mitigate HP-induced gastritis and psychiatric disorder in mice. Oral administration of P135 and\/or P142 alleviated HP- or aspirin-induced gastritis, colitis, neuroinflammation, and depression\/cognitive impairment-like behavior. They also suppressed HP infection, neutrophil infiltration, and NF-\u03baB activation in the stomach and TNF-\u03b1 expression and NF-\u03baB activation in the colon and hippocampus. of P135 and\/or P142 alleviated HP- or aspirin-induced gut dysbiosis: they decreased Lachnospiracease, Helicobacteriaceae, and Akkermansiaceae populations and increased Bacteroidaceae and Muribaculaceae populations. These findings suggest that HP growth\/inflammation-inhibitory P135 and\/or P142 may alleviate gut inflammation (gastritis and colitis) and neuroinflammation through the suppression of neutrophil infiltration, NF-\u03baB activation, and HP growth, thereby leading to the attenuation of systemic inflammation and psychiatric disorder.<\/jats:p>","DOI":"10.1093\/lambio\/ovae128","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T07:06:08Z","timestamp":1734073568000},"source":"Crossref","is-referenced-by-count":3,"title":["Alleviation of <i>Helicobacter pylori<\/i>- or aspirin-induced gastritis and neuroinflammation in mice by <i>Lactococcus lactis<\/i> and <i>Bifidobacterium longum<\/i>"],"prefix":"10.1093","volume":"77","author":[{"given":"Jung-Woo","family":"Shin","sequence":"first","affiliation":[{"name":"Neurobiota Research Center, College of Pharmacy, Kyung Hee University , 26, Kyungheedae-ro, Dongdaemun-gu , Seoul 02447 ,","place":["Republic of 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