{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:16:32Z","timestamp":1791861392468,"version":"4.3.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009526","name":"Amrita Vishwa Vidyapeetham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mycobacterium marinum is a slow growing Non-Tuberculosis Mycobacteria known to cause skin and subcutaneous tissue infections known as \u201cfish tank granuloma\u201d in humans. Treatment of M. marinum skin infections can last for several months or even years. Intravenous or intramuscular administration of Amikacin, a bactericidal inhibitor, in a multidrug regimen is a good therapeutic option in treating M. marinum infections. No topical hydrogels are currently available to treat M. marinum skin infections. We developed a 2.5% amikacin-loaded carbopol hydrogel containing the permeation enhancers 1% Tween-80 and 1% PEG (AMK-CPTP) for topical application to treat M. marinum skin infections. A molecular docking study of carbopol\u2013Amikacin interaction predicted a stable structure and was confirmed with rheological characterization. The developed gel was found to be non-hemolytic, cytocompatible, and non-irritant. Sustained release of Amikacin from the AMK-CPTP hydrogel was observed, with a release of 60% Amikacin after 48\u00a0h. The antibacterial activity and skin permeability of amikacin released from AMK-CPTP were assessed using both in vitro and ex vivo assays. Overall. AMK-CPTP demonstrated anti-microbial activity against M. marinum with a 35% increase in skin permeation on the addition of Tween-80 and PEG. AMK-CPTP could be used to treat M. marinum skin infections.<\/jats:p>","DOI":"10.1093\/lambio\/ovae134","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T03:35:51Z","timestamp":1735097751000},"source":"Crossref","is-referenced-by-count":3,"title":["Development and evaluation of Amikacin-loaded carbopol hydrogel for topical treatment of <i>Mycobacterium marinum<\/i> skin infections"],"prefix":"10.1093","volume":"78","author":[{"given":"Praise Mary","family":"Francis","sequence":"first","affiliation":[{"name":"Amrita School for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham , Kochi 682041 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Vinod","sequence":"additional","affiliation":[{"name":"Amrita School for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham , Kochi 682041 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V Anil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham , Kochi 682041 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Gopi","family":"Mohan","sequence":"additional","affiliation":[{"name":"Amrita School for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham , Kochi 682041 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Biswas","sequence":"additional","affiliation":[{"name":"Amrita School for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham , Kochi 682041 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